ChemicalBook > CAS DataBase List > N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan

N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan

Product Name
N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan
CAS No.
185351-19-3
Chemical Name
N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan
Synonyms
NQTrp;NQTrp >=98% (HPLC);1,4-Naphthoquinon-2-yl-l-tryptophan;N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan;L-Tryptophan, N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)-;(S)-2-((1,4-Dioxo-1,4-dihydronaphthalen-2-yl)amino)-3-(1H-indol-3-yl)propanoic acid;(2S)-2-[(1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino]-3-(1H-indol-3-yl)propanoic acid
CBNumber
CB52751095
Molecular Formula
C21H16N2O4
Formula Weight
360.36
MOL File
185351-19-3.mol
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N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan Property

Melting point:
208.0-211.0 °C
Boiling point:
658.9±55.0 °C(Predicted)
Density 
1.45±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
pka
3.89±0.10(Predicted)
color 
orange to dark orange-red
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1104
Product name
NQTrp
Purity
≥98% (HPLC)
Packaging
5mg
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1104
Product name
NQTrp
Purity
≥98% (HPLC)
Packaging
25mg
Price
$476
Updated
2024/03/01
Cayman Chemical
Product number
19127
Product name
NQTrp
Purity
≥98%
Packaging
1mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
19127
Product name
NQTrp
Purity
≥98%
Packaging
5mg
Price
$94
Updated
2024/03/01
Cayman Chemical
Product number
19127
Product name
NQTrp
Purity
≥98%
Packaging
10mg
Price
$140
Updated
2024/03/01
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N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan Chemical Properties,Usage,Production

Description

NQTrp is an inhibitor of Alzheimer’s disease-associated amyloid β (Aβ) oligomerization and fibrillization (IC50 = 50 nM for formation of fibrils from Aβ1-42). It has been shown to reduce the cytotoxic effect of Aβ oligomers in a cultured neuronal cell line.

Uses

NQTrp is a inhibitor of Aβ1-42 aggregation, altering Aβ self-assembly and reducing toxicity.

References

[1]. scherzer-attali r, pellarin r, convertino m, et al. complete phenotypic recovery of an alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor. plos one. 2010 jun 14;5(6):e11101.
[2]. zhang t, xu w, mu y, et al. atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-l-tryptophan inhibitor on alzheimer's aβ1-42 dimer in terms of aggregation and toxicity. acs chem neurosci. 2014 feb 19;5(2):148-59.

N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan Suppliers

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185351-19-3, N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophanRelated Search:


  • 1,4-Naphthoquinon-2-yl-l-tryptophan
  • N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan
  • NQTrp
  • L-Tryptophan, N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)-
  • NQTrp >=98% (HPLC)
  • (S)-2-((1,4-Dioxo-1,4-dihydronaphthalen-2-yl)amino)-3-(1H-indol-3-yl)propanoic acid
  • (2S)-2-[(1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino]-3-(1H-indol-3-yl)propanoic acid
  • 185351-19-3