1-BROMOMETHYL-ISOQUINOLINE
- Product Name
- 1-BROMOMETHYL-ISOQUINOLINE
- CAS No.
- 74417-44-0
- Chemical Name
- 1-BROMOMETHYL-ISOQUINOLINE
- Synonyms
- 1-BROMOMETHYL-ISOQUINOLINE;Isoquinoline, 1-(bromomethyl)-
- CBNumber
- CB5276389
- Molecular Formula
- C10H8BrN
- Formula Weight
- 222.08
- MOL File
- 74417-44-0.mol
1-BROMOMETHYL-ISOQUINOLINE Property
- Melting point:
- 56℃
- Boiling point:
- 322.1±17.0 °C(Predicted)
- Density
- 1.518
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 3.90±0.30(Predicted)
- Appearance
- Pale purple to purple Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B847213
- Product name
- 1-(Bromomethyl)isoquinoline
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B847213
- Product name
- 1-(Bromomethyl)isoquinoline
- Packaging
- 50mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- B847213
- Product name
- 1-(Bromomethyl)isoquinoline
- Packaging
- 100mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- FB142873
- Product name
- 1-(Bromomethyl)isoquinoline
- Packaging
- 100mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 9770AH
- Product name
- 1-Bromomethyl-isoquinoline
- Packaging
- 250mg
- Price
- $171
- Updated
- 2021/12/16
1-BROMOMETHYL-ISOQUINOLINE Chemical Properties,Usage,Production
Synthesis
1721-93-3
74417-44-0
The general procedure for the synthesis of 1-(bromomethyl)isoquinoline from 1-methylisoquinoline is as follows: 1. 1-methylisoquinoline (0.99 g, 6.91 mmol), N-bromosuccinimide (NBS, 1.35 g, 1.1 eq.), azobisisobutyronitrile (AIBN, 10 mg, catalytic amount), and carbon tetrachloride (CCl4, 1 mL) were added to a reaction flask. 2. The reaction mixture was heated to reflux for 2 hours. 3. Upon completion of the reaction, the suspended solid particles were removed by filtration and the solids were washed with a small amount of CCl4. 4. The filtrate and washings were combined and concentrated under reduced pressure to remove the solvent. 5. The crude product was purified by column chromatography (eluent: 30% ethyl acetate/hexane) to afford 1-(bromomethyl)isoquinoline (270 mg, yield: 18%) as a violet solid. 6. The structure of the product was determined by 1H-1H-quinolysis. 6. The structure of the product was confirmed by 1H-NMR (500 MHz, CDCl3): δ 8.48 (d, 1H), 8.25 (d, 1H), 7.87 (d, 1H), 7.75-7.67 (m, 2H), 7.65 (d, 1H).
References
[1] Patent: WO2008/16239, 2008, A1. Location in patent: Page/Page column 57-58
1-BROMOMETHYL-ISOQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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