CIS-13,16,19-DOCOSATRIENOIC ACID METHYL ESTER

CIS-13,16,19-DOCOSATRIENOIC ACID METHYL ESTER Property

Boiling point:

427.0±14.0 °C(Predicted)

Density 

0.888±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 100 mg/ml

Safety

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

CIS-13,16,19-DOCOSATRIENOIC ACID METHYL ESTER Chemical Properties,Usage,Production

Description

Docosatrienoic acid methyl ester is an ester version of docosatrienoic acid , a rare ω-3 fatty acid not readily detected in normal phospholipid polyunsaturated fatty acid pools that inhibits [³H]-LTB₄ binding to pig neutrophils at a concentration of 5 μM. Docosatrienoic acid methyl ester is more lipid soluble than the free acid and may be more desirable than the free acid in certain formulations.

Uses

cis-13,16,19-Docosatrienoic acid methyl ester is an ester form of docosatrienoic acid, a rare omega-3 fatty acid not found in the normal phospholipid polyunsaturated fatty acid pool Easily detectable, it inhibits the binding of [3H]-LTB4 to porcine neutrophils at a concentration of 5 μM. Methyl docosatrienoate is more fat-soluble than the free acid and may be more desirable than the free acid in some formulations.

References

[1] K.A. YAGALOFF. Essential fatty acids are antagonists of the leukotriene B4 receptor[J]. Prostaglandins, leukotrienes, and essential fatty acids, 1995, 52 5: Pages 293-297. DOI: 10.1016/0952-3278(95)90029-2