GRANULIBERIN R
- Product Name
- GRANULIBERIN R
- CAS No.
- 64704-41-2
- Chemical Name
- GRANULIBERIN R
- Synonyms
- GRANULIBERIN R;FGFLPIYRRPAS-NH2;Granuliberin R, ≥97% (HPLC);PHE-GLY-PHE-LEU-PRO-ILE-TYR-ARG-ARG-PRO-ALA-SER-NH2;H-PHE-GLY-PHE-LEU-PRO-ILE-TYR-ARG-ARG-PRO-ALA-SER-NH2;L-Phenylalanylglycyl-L-phenylalanyl-L-leucyl-L-prolyl-L-isoleucyl-L-tyrosyl-L-arginyl-L-arginyl-L-prolyl-L-alanyl-L-serinamide;L-Serinamide, L-phenylalanylglycyl-L-phenylalanyl-L-leucyl-L-prolyl-L-isoleucyl-L-tyrosyl-L-arginyl-L-arginyl-L-prolyl-L-alanyl-
- CBNumber
- CB5287743
- Molecular Formula
- C69H103N19O14
- Formula Weight
- 1422.68
- MOL File
- 64704-41-2.mol
GRANULIBERIN R Property
- storage temp.
- −20°C
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- G8940
- Product name
- Granuliberin-R
- Packaging
- 1mg
- Price
- $531
- Updated
- 2021/12/16
- Product number
- PEP0001651
- Product name
- GRANULIBERIN R
- Purity
- 95.00%
- Packaging
- 2MG
- Price
- $619.08
- Updated
- 2021/12/16
- Product number
- PEP0001651
- Product name
- GRANULIBERIN R
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $762.94
- Updated
- 2021/12/16
GRANULIBERIN R Chemical Properties,Usage,Production
Uses
Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa. Granuliberin R is a dodecapeptide, can act on rat peritoneal mast cell to liberate granules and release histamine[1][2].
in vivo
Granuliberin R (0.1 mg/mL, 1 μg/mL, and 10 ng/mL; injection; single dose for 60 s) interfere in the proliferation of oral keratinocytes and the activity of connective tissue cells when treatment is conducted into rats mandibular gingiva in the vicinity of the right mental foramen[4].
References
[1] Nakajima T, et al. A new mast cell degranulating peptide, granuliberin-R, in the frog (Rana rugosa) skin. Chem Pharm Bull (Tokyo). 1977 Sep;25(9):2464-5. DOI:10.1248/cpb.25.2464
[2] Yasuhara T, et al. The studies on the active peptide in the skin of Rana rugosa. II. The structure of ranatensin-R, the new ranatensin analogue, and granuliberin-R, the new mast cell degranulating peptide. Chem Pharm Bull (Tokyo). 1979 Feb;27(2):492-8. DOI:10.1248/cpb.27.492
[3] Vitale N, et al. Exocytosis in chromaffin cells: evidence for a MgATP-independent step that requires a pertussis toxin-sensitive GTP-binding protein. Biochem J. 1994 May 15;300 ( Pt 1)(Pt 1):217-27. DOI:10.1042/bj3000217
[4] Kozakiewicz M, et al. Modulation of the mitotic activity and population of the mast cells in the oral mucosa by substance P. Cell Mol Biol Lett. 2003;8(3):727-34. PMID:12949612
GRANULIBERIN R Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from GRANULIBERIN R manufacturers
- Product
- GRANULIBERIN R 64704-41-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- g/kg/Ton
- Release date
- 2020-03-05