3-CHLORO-5-CYANO-BENZOIC ACID
- Product Name
- 3-CHLORO-5-CYANO-BENZOIC ACID
- CAS No.
- 327056-71-3
- Chemical Name
- 3-CHLORO-5-CYANO-BENZOIC ACID
- Synonyms
- 3-CHLORO-5-CYANO-BENZOIC ACID;Benzoic acid, 3-chloro-5-cyano-
- CBNumber
- CB5291643
- Molecular Formula
- C8H4ClNO2
- Formula Weight
- 181.58
- MOL File
- 327056-71-3.mol
3-CHLORO-5-CYANO-BENZOIC ACID Property
- Boiling point:
- 329.0±27.0 °C(Predicted)
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.27±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- 3680AB
- Product name
- 3-Chloro-5-cyanobenzoicacid
- Packaging
- 250mg
- Price
- $253
- Updated
- 2021/12/16
- Product number
- HCH0364825
- Product name
- 3-CHLORO-5-CYANOBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.27
- Updated
- 2021/12/16
- Product number
- A279796
- Product name
- 3-Chloro-5-cyanobenzoicacid
- Purity
- 95%
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- A279796
- Product name
- 3-Chloro-5-cyanobenzoicacid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CD12083434
- Product name
- 3-Chloro-5-cyanobenzoicacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $297
- Updated
- 2021/12/16
3-CHLORO-5-CYANO-BENZOIC ACID Chemical Properties,Usage,Production
Synthesis
914106-36-8
2905-67-1
327056-71-3
Methyl 3,5-dichlorobenzoate (14.66 g, 71.5 mmol) was used as a raw material, and was mixed with zinc cyanide (5.04 g, 42.9 mmol), zinc powder (0.21 g, 3.21 mmol), and [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride complex with dichloromethane (1:1) (1.3 g, 1.57 mmol) in N ,N-dimethylformamide (70 mL) was mixed and heated to reflux for 5 hours. After completion of the reaction, it was cooled to room temperature, the reaction mixture was diluted with ethyl acetate and extracted sequentially with water and brine. Purification by silica gel column chromatography afforded 2.34 g (17% yield) of methyl 2-chloro-5-cyanobenzoate. The intermediate ester was dissolved in methanol (50 mL), 4 N sodium hydroxide solution (7.5 mL, 30 mmol) was added, and stirred at room temperature for 18 hours. At the end of the reaction, the solvent was removed under vacuum, the residue was dissolved in ethyl acetate and the organic phase was washed sequentially with 5% HCl and brine. Finally, the solvent was removed to give 1.8 g (83% yield) of 3-chloro-5-cyanobenzoic acid.
References
[1] Patent: US2003/55085, 2003, A1
3-CHLORO-5-CYANO-BENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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