ChemicalBook > CAS DataBase List > 1-METHYL-1H-INDOLE-5-CARBALDEHYDE

1-METHYL-1H-INDOLE-5-CARBALDEHYDE

Product Name
1-METHYL-1H-INDOLE-5-CARBALDEHYDE
CAS No.
90923-75-4
Chemical Name
1-METHYL-1H-INDOLE-5-CARBALDEHYDE
Synonyms
1-Methylindolecarbaldehyde;5-Formyl-1-methyl-1H-indole;1-Methylindole-5-carbaldehyde;1-Methylindole-5-carboxaldehyde;1-METHYL-1H-INDOLE-5-CARBALDEHYDE;1-METHYL-1H-INDOLE-5-CARBOXALDEHYDE;1H-Indole-5-carboxaldehyde, 1-methyl-;1-Methyl-1H-indole-5-carboxaldehyde97%;1-Methyl-1H-indole-5-carboxaldehyde 97%;1-Methyl-1H-indole-5-carboxaldehyde
CBNumber
CB5294013
Molecular Formula
C10H9NO
Formula Weight
159.18
MOL File
90923-75-4.mol
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1-METHYL-1H-INDOLE-5-CARBALDEHYDE Property

Melting point:
84-85.5
Boiling point:
318.7±15.0 °C(Predicted)
Density 
1.10±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
form 
Solid
Appearance
Off-white to light yellow Solid
Sensitive 
Air & Moisture Sensitive
InChI
InChI=1S/C10H9NO/c1-11-5-4-9-6-8(7-12)2-3-10(9)11/h2-7H,1H3
InChIKey
XIVDZBIBWGQOTI-UHFFFAOYSA-N
SMILES
N1(C)C2=C(C=C(C=O)C=C2)C=C1
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36
WGK Germany 
3
Hazard Note 
Harmful
HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
774561
Product name
1-Methyl-1H-indole-5-carboxaldehyde
Purity
97%
Packaging
500mg
Price
$140.7
Updated
2025/07/31
TRC
Product number
M219168
Product name
1-Methyl-1H-indole-5-carbaldehyde
Packaging
100mg
Price
$65
Updated
2021/12/16
ChemScene
Product number
CS-0061753
Product name
1-Methyl-1H-indole-5-carbaldehyde
Purity
98.89%
Packaging
250mg
Price
$50
Updated
2021/12/16
Apolloscientific
Product number
OR9157
Product name
1-Methyl-1H-indole-5-carboxaldehyde
Purity
97%
Packaging
250mg
Price
$59
Updated
2021/12/16
Apolloscientific
Product number
OR9157
Product name
1-Methyl-1H-indole-5-carboxaldehyde
Purity
97%
Packaging
1g
Price
$75
Updated
2021/12/16
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1-METHYL-1H-INDOLE-5-CARBALDEHYDE Chemical Properties,Usage,Production

Synthesis

1196-69-6

74-88-4

90923-75-4

To a solution of 5-indolecarboxaldehyde (1.0 g, 6.9 mmol) in N,N-dimethylformamide (DMF, 15 mL) was added sodium hydride (303 mg, 60% oil dispersion, 7.59 mmol) in one portion. The reaction mixture was stirred at room temperature for 30 minutes. Subsequently, iodomethane (1.96 g, 13.8 mmol) was added to the reaction system and the mixture was continued to stir overnight. Upon completion of the reaction, ethyl acetate (200 mL) was added to dilute the reaction mixture, and the organic phase was washed sequentially with water (3 x 20 mL) and saturated saline (25 mL). The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated to afford 1-methyl-1H-indole-5-carbaldehyde as an orange oil (1.0 g, 91% yield). The product was characterized by 1H NMR (200 MHz, CDCl3): δ 10.05 (s, 1H), 8.09 (s, 1H), 7.90-7.80 (m, 1H), 7.35-7.15 (m, 2H), 6.85-6.80 (m, 1H), 3.95 (s, 3H).

References

[1] Patent: WO2004/52890, 2004, A1. Location in patent: Page 91-92
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 7, p. 2060 - 2079
[3] European Journal of Medicinal Chemistry, 2018, vol. 158, p. 167 - 183
[4] Patent: US2005/209274, 2005, A1. Location in patent: Page/Page column 27
[5] Journal of Organometallic Chemistry, 2011, vol. 696, # 5, p. 1072 - 1083

1-METHYL-1H-INDOLE-5-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-METHYL-1H-INDOLE-5-CARBALDEHYDE manufacturers

Nanjing jinheyou Trading Co., Ltd.
Product
1-METHYL-1H-INDOLE-5-CARBALDEHYDE 90923-75-4
Price
US $0.00/g
Min. Order
1g
Purity
95%min
Supply Ability
20kg/month
Release date
2019-12-19

90923-75-4, 1-METHYL-1H-INDOLE-5-CARBALDEHYDERelated Search:


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