1-(4-Trifluoromethylphenyl)piperidin-4-ol

Product Name: 1-(4-Trifluoromethylphenyl)piperidin-4-ol
CAS No.: 681508-70-3
Chemical Name: 1-(4-Trifluoromethylphenyl)piperidin-4-ol
Synonyms: 4-(6-Bromo-pyridin-2-yl)-benzoicacid;1-(4-TRIFLUOROMETHYLPHENYL)PIPERIDIN-4-OL;1-[4-(trifluoromethyl)phenyl]-4-piperidinol;4-Piperidinol, 1-[4-(trifluoromethyl)phenyl]-
CBNumber: CB5299720
Molecular Formula: C12H14F3NO
Formula Weight: 245.24
MOL File: 681508-70-3.mol

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1-(4-Trifluoromethylphenyl)piperidin-4-ol Property

Boiling point:: 334.3±42.0 °C(Predicted)
Density: 1.275±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.72±0.20(Predicted)
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: V0025
Product name: 1-(4-Trifluoromethylphenyl)piperidin-4-ol
Packaging: 1g
Price: $115
Updated: 2021/12/16

AK Scientific

Product number: V0025
Product name: 1-(4-Trifluoromethylphenyl)piperidin-4-ol
Packaging: 10g
Price: $411
Updated: 2021/12/16

Matrix Scientific

Product number: 071783
Product name: 1-(4-Trifluoromethylphenyl)piperidin-4-ol
Purity: 95+%
Packaging: 5g
Price: $500
Updated: 2021/12/16

Matrix Scientific

Product number: 071783
Product name: 1-(4-Trifluoromethylphenyl)piperidin-4-ol
Purity: 95+%
Packaging: 1g
Price: $185
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: COR0001144
Product name: 1-(4-TRIFLUOROMETHYLPHENYL)PIPERIDIN-4-OL
Purity: 95.00%
Packaging: 1G
Price: $202.65
Updated: 2021/12/16

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1-(4-Trifluoromethylphenyl)piperidin-4-ol Chemical Properties,Usage,Production

Synthesis

5382-16-1

402-43-7

681508-70-3

Under nitrogen atmosphere, BINAP (187 mg, 0.3 mmol), Pd2(dba)3 (92 mg, 0.1 mmol), sodium tert-butoxide (1.19 g, 12.0 mmol), 4-hydroxypiperidine (Compound 8, 1.14 g, 11.2 mmol), and p-bromobenzotrifluoride (Compound 9, 1.36 mL, 10.0 mmol) were were dissolved in toluene. The reaction mixture was subjected to microwave radiation and reacted at 120°C for 1 hour. Upon completion of the reaction, the reaction solution was filtered through diatomaceous earth and the solids were washed with ethyl acetate. The filtrate and washings were combined and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate gradient) to afford 1-(4-trifluoromethylphenyl)piperidin-4-ol (Compound 10, 1.45 g, 59% yield). The melting point of the product was 97-98 °C. 1H-NMR (CDCl3/TMS) δ ppm: 1.49-1.56 (m, 2H), 1.62-1.74 (m, 2H), 2.03 (brs, 2H), 3.03-3.10 (m, 2H), 3.63-3.71 (m, 2H), 3.93 (brs, 1H), 6.97 ( br, 2H), 7.48 (d, J = 8.7 Hz, 2H).

References

[1] Journal of the American Chemical Society, 2018, vol. 140, # 24, p. 7667 - 7673
[2] Angewandte Chemie - International Edition, 2017, vol. 56, # 42, p. 13088 - 13093
[3] Angew. Chem., 2017, vol. 129, p. 13268 - 13273,6
[4] Patent: EP1988077, 2008, A1. Location in patent: Page/Page column 63-64
[5] Patent: WO2010/115688, 2010, A1. Location in patent: Page/Page column 127

1-(4-Trifluoromethylphenyl)piperidin-4-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-Trifluoromethylphenyl)piperidin-4-ol Suppliers

China 37 Germany 1 India 2 United Kingdom 1 United States 13 Global 54

Shanghai Hanhong Scientific Co.,Ltd.

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View Lastest Price from 1-(4-Trifluoromethylphenyl)piperidin-4-ol manufacturers

Career Henan Chemical Co

Product: 1-(4-Trifluoromethylphenyl)piperidin-4-ol 681508-70-3
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-04

681508-70-3, 1-(4-Trifluoromethylphenyl)piperidin-4-olRelated Search:

DROPERIDOL 2,2,6,6-Tetramethylpiperidinooxy 2,2,6,6-Tetramethyl-4-piperidinol Haloperidol 1-(2-NITRO-5-TRIFLUOROMETHYLPHENYL)PIPERIDIN-4-OL (8-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]-3-PHENYL-1-OXA-4,8-DIAZASPIRO[4.5]DEC-4-YL)(4-FLUOROPHENYL)METHANONE 1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]PIPERIDIN-4-OL 1-[2-amino-4-(trifluoromethyl)phenyl]piperidin-4-ol 8-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]-N-(4-METHYLPHENYL)-3-PHENYL-1-OXA-4,8-DIAZASPIRO[4.5]DECANE-4-CARBOXAMIDE 3-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]-7,12-DIOXA-3-AZASPIRO[5.6]DODEC-9-ENE 4,5-BIS(HYDROXYMETHYL)-3-HYDRAZIDO-4,5-DIHYDROISOXAZOLE-1(2,6-DINITRO-4-TRIFLUOROMETHYLPHENYL)PIPERID-4-ONE ACETAL [3-ETHOXYCARBONYL-4,5-BIS(HYDROXYMETHYL)-4,5-DIHYDROISOXAZOLE][1-(2,6-DINITRO-4-TRIFLUOROMETHYLPHENYL)-4-PIPERIDONE]KETAL 8-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]-1,4-DIOXA-8-AZASPIRO-[4,5]-DECANE 1-(4-Trifluoromethylphenyl)piperidin-4-ol

1-(4-TRIFLUOROMETHYLPHENYL)PIPERIDIN-4-OL

4-(6-Bromo-pyridin-2-yl)-benzoicacid

1-[4-(trifluoromethyl)phenyl]-4-piperidinol

4-Piperidinol, 1-[4-(trifluoromethyl)phenyl]-

681508-70-3

C13H18F3NO