3-HYDROXYBENZOPHENONE Property

Melting point:

113-115 °C (lit.)

Boiling point:

295.53°C (rough estimate)

Density 

1.1184 (rough estimate)

refractive index 

1.5954 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Soluble in Chloroform, DCM. Ethyl Acetate.

pka

9.18±0.10(Predicted)

form 

Solid

color 

White

λmax

315nm(EtOH)(lit.)

CAS DataBase Reference

13020-57-0(CAS DataBase Reference)

NIST Chemistry Reference

M-hydroxybenzophenone(13020-57-0)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-36

WGK Germany 

3

RTECS 

PC4959730

HazardClass 

IRRITANT

HS Code 

29145090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

3-HYDROXYBENZOPHENONE Chemical Properties,Usage,Production

Chemical Properties

light beige to brown-grey crystalline powder

Uses

3-Hydroxybenzophenone is a benzophenone metabolite with potential estrogenic and anti-androgenic activity. is a more attractive hydrogen bonding co-material for MCPBA, as the 3-hydroxyl group is unable to form an intramolecular hydrogen bond. It is commonly used as a radical and cationic photo initiators.

Preparation

Preparation by aromatization of 5-benzoyl-2- cyclohexenone,
? in the presence of 10% Pd/C in refluxing xylene for 6 h (60%)
? in the presence of lithium bromide and cupric bromide in refluxing acetonitrile for 1 h (75%).