D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2
- Product Name
- D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2
- CAS No.
- 81039-85-2
- Chemical Name
- D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2
- Synonyms
- pro(4)-trp(7,9)-substancep(4-11;Substance P, [D-Pro4, D-Trp7,9];substance P (4-11), Pro(4)-Trp(7,9)-;(D-PRO4,D-TRP7,9)-SUBSTANCE P (4-11);D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2;H-D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2;[D-PRO4,D-TRP7,9]-SUBSTANCE P (4-11) ACOH 4H2O;D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 ACOH 4H2O;DPRO-GLN-GLN-DTRP-PHE-DTRP-LEU-MET-NH2: DP-QQ-DW-F-DW-LM-NH2;D-Pro-L-Glu(NH2)-L-Glu(NH2)-D-Trp-L-Phe-D-Trp-L-Leu-L-Met-NH2
- CBNumber
- CB5302273
- Molecular Formula
- C57H75N13O10S
- Formula Weight
- 1134.35
- MOL File
- 81039-85-2.mol
N-Bromosuccinimide Price
- Product number
- S8000-14R
- Product name
- Substance P [D-Pro4, D-Trp7,9]
- Packaging
- 1mg
- Price
- $531
- Updated
- 2021/12/16
- Product number
- INB0001583
- Product name
- [DPRO4DTRP79]SUBSTANCE P(4-11)
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $612.15
- Updated
- 2021/12/16
D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 Chemical Properties,Usage,Production
Uses
[D-Pro4,D-Trp7,9] Substance P (4-11) is a potent antagonist of Substance P (HY-P0201). [D-Pro4,D-Trp7,9] Substance P (4-11) decreases plasma aldosterone (ALDO) concentration[1].
in vivo
[D-Pro4,D-Trp7,9] Substance P (4-11) inhibits the hypotensive effect of Substance P in anesthetized rats, the vasodilator effect in the rabbit perfused heart, relaxation induced by Substance P in dog carotid arteries contracted with noradrenaline, and stimulatory actions of Substance P in the guinea pig ileum and the guinea pig trachea[1]. [D-Pro4,D-Trp7,9] Substance P (4-11) (0.3 nM/K/min; i.p. for 7 days) significantly decreases plasma aldosterone (ALDO) concentration and causes atrophy of adrenal zona glomerulosa (ZG) and its parenchymal cells[2].
References
[1] Mizrahi J, et al. Substance P antagonists active in vitro and in vivo. Eur J Pharmacol. 1982 Aug 13;82(1-2):101-5. DOI:10.1016/0014-2999(82)90561-1
[2] Mazzocchi G, et al. Evidence that endogenous substance-P (SP) is involved in the maintenance of the growth and steroidogenic capacity of rat adrenal zona glomerulosa. Neuropeptides. 1995 Jul;29(1):53-8. DOI:10.1016/0143-4179(95)90056-x
D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 Preparation Products And Raw materials
Raw materials
Preparation Products
D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 Suppliers
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- 21-61263452 13641803416
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View Lastest Price from D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 manufacturers
- Product
- D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 81039-85-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- g/kg/Ton
- Release date
- 2020-03-05