ethyl 4-chloro-5-methyl-5h-pyrrolo[3,2-d]pyrimidine-7-carboxylate
- Product Name
- ethyl 4-chloro-5-methyl-5h-pyrrolo[3,2-d]pyrimidine-7-carboxylate
- CAS No.
- 1234616-53-5
- Chemical Name
- ethyl 4-chloro-5-methyl-5h-pyrrolo[3,2-d]pyrimidine-7-carboxylate
- Synonyms
- Ethyl 4-chloro-5-methyl-pyrrolo[3,2-d]pyrimidine-7-carboxylate;ethyl 4-chloro-5-methyl-5h-pyrrolo[3,2-d]pyrimidine-7-carboxylate;5H-Pyrrolo[3,2-d]pyrimidine-7-carboxylic acid, 4-chloro-5-methyl-, ethyl ester
- CBNumber
- CB53032876
- Molecular Formula
- C10H10ClN3O2
- Formula Weight
- 239.66
- MOL File
- 1234616-53-5.mol
ethyl 4-chloro-5-methyl-5h-pyrrolo[3,2-d]pyrimidine-7-carboxylate Property
- Boiling point:
- 382.8±37.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.57±0.40(Predicted)
- Appearance
- yellow solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B125420
- Product name
- Ethyl4-Chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4H58-5-A1
- Product name
- Ethyl 4-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine-3-carboxylate
- Packaging
- 250mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- HCH0620808
- Product name
- ETHYL-4-CHLORO-5-METHYL-5H-PYRROLO[3,2-D]PYRIMIDINE-7-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.78
- Updated
- 2021/12/16
- Product number
- 4H58-5-A1
- Product name
- Ethyl 4-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine-3-carboxylate
- Packaging
- 1g
- Price
- $625
- Updated
- 2021/12/16
- Product number
- 112316
- Product name
- Ethyl 4-chloro-5-methyl-5H-pyrrolo-[3,2-d]pyrimidine-7-carboxylate
- Packaging
- 1g
- Price
- $662
- Updated
- 2021/12/16
ethyl 4-chloro-5-methyl-5h-pyrrolo[3,2-d]pyrimidine-7-carboxylate Chemical Properties,Usage,Production
Synthesis
853058-42-1
74-88-4
1234616-53-5
Ethyl 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate (500 mg, 2.22 mmol) was dissolved in N,N-dimethylformamide (4 mL, 50 mmol) and the solution was cooled to 0 °C. Sodium hydride (60% dispersed in mineral oil, 115.2 mg) was added to the solution at 0 °C and the reaction mixture was stirred for 20 min. Subsequently, iodomethane (165.5 μL, 2.659 mmol) was added and the reaction mixture was slowly warmed to room temperature. Upon completion of the reaction, the reaction was quenched with aqueous ammonium chloride and extracted three times with dichloromethane. The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by fast column chromatography (elution gradient: 0-100% heptane solution of ethyl acetate containing 15% methanol) to afford ethyl 4-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate as a solid (380 mg in 72% yield).1H NMR (500 MHz, DMSO-d6) δ 8.77 (s, 1H) 8.65 (s, 1H), 4.30 (q, J = 7.1 Hz, 2H), 4.16 (s, 3H), 1.32 (t, J = 7.1 Hz, 3H).
References
[1] Patent: WO2011/25940, 2011, A1. Location in patent: Page/Page column 85-86
ethyl 4-chloro-5-methyl-5h-pyrrolo[3,2-d]pyrimidine-7-carboxylate Preparation Products And Raw materials
Raw materials
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