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CDKI-73

Product Name
CDKI-73
CAS No.
1421693-22-2
Chemical Name
CDKI-73
Synonyms
CS-2259;CDKI-73;asnuciclib;CDKI-73 ，S7773;CDKI-73 (CDKI73);Asnuciclib (CDKI-73);CDKI-73, 10 mM in DMSO;3-((5-Fluoro-4-(4-methyl-2-(methylamino)thiazol-5-yl)pyrimidin-2-yl)amino)benzenesulfonamide;3-[[5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-2-pyrimidinyl]amino]-benzenesulfonamide;Benzenesulfonamide, 3-[[5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-2-pyrimidinyl]amino]-
CBNumber
CB53034461
Molecular Formula
C15H15FN6O2S2
Formula Weight
394.45
MOL File
1421693-22-2.mol
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CDKI-73 Property

Boiling point:
642.9±65.0 °C(Predicted)
Density 
1.524±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:52.0(Max Conc. mg/mL);131.83(Max Conc. mM)
form 
Solid
pka
10.06±0.60(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-3953
Product name
CDKI-73
Purity
99.58%
Packaging
5mg
Price
$420
Updated
2021/12/16
ChemScene
Product number
CS-3953
Product name
CDKI-73
Purity
99.58%
Packaging
10mg
Price
$600
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611582
Product name
CDKI-73
Packaging
100mg
Price
$1060.8
Updated
2021/12/16
ChemScene
Product number
CS-3953
Product name
CDKI-73
Purity
99.58%
Packaging
50mg
Price
$1800
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611582
Product name
CDKI-73
Packaging
250mg
Price
$2097.8
Updated
2021/12/16
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CDKI-73 Chemical Properties,Usage,Production

Uses

3-[[5-Fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-2-pyrimidinyl]amino]benzenesulfonamide is a potent CDK inhibitor. A highly efficacious CDK9 inhibitor against acute myeloid leukemia.

in vivo

Asnuciclib (25, 50, 100 mg/kg) markedly decreases tumor growth in a dose-dependent manner and results in a prolongation of animal life span (P < 0.001) without causing body weight loss and other overt toxicities.[3].

Animal Model:MV4-11 tumor bearing mice[3].
Dosage:25 mg/kg.
Administration:Orally once everyday for 33 days.
Result:Caused a remarkable delay in tumor growth compared to vehicle-treated mice, as reflected in a percentage for the mean tumor volume in treated to control mice of 43% at day 31.
Animal Model:Balb/C mice aged 6-8 weeks[3].
Dosage:2 mg/kg (IV), 10, 20 and 40 mg/kg (PO). (Pharmacokinetic Analysis.)
Administration:IV and PO, single dose.
Result:The Cmax increased from 1.29 to 3.66 μM at a mean time of 1 h and the area under the curve (AUC) of CDKI-73 increased from 3.51 to 12.8 μM.h when the oral dose was escalated from 10 to 40 mg/kg.
CDKI-73 was eliminated from plasma with a mean terminal half-life (T1/2) of 2 h. Its oral bioavailability (F) ranged from 54 to 85% across the three doses.

IC 50

CDK2: 3.27 nM (IC50); CDK9: 5.78 nM (IC50); CDK1: 8.17 nM (IC50); CDK4: 8.18 nM (IC50); CDK6: 37.68 nM (IC50); CDK7: 134.26 nM (IC50); CDK1: 4 nM (Ki); CDK2: 3 nM (Ki); CDK9: 4 nM (Ki); CDK7: 91 nM (Ki)

CDKI-73 Preparation Products And Raw materials

Raw materials

Preparation Products

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CDKI-73 Suppliers

China 62 United States 9 Global 71
BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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United States
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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China
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Shanghaizehan biopharma technology co., Ltd.
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021-61350663 13052117465
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021-61350662
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sales@zehanbiopharma.com
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China
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BOC Sciences
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16314854226
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info@bocsci.com
Country
United States
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
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Shanghai Rechem science Co., Ltd.
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021-31433387 15618786686
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QQ:1369748377
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sales@rechemscience.com
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China
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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China
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
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131957
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 18892239720
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010-60605840
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psaitong@jm-bio.com
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China
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1421693-22-2, CDKI-73Related Search:


  • CDKI-73
  • CS-2259
  • CDKI-73 (CDKI73)
  • Benzenesulfonamide, 3-[[5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-2-pyrimidinyl]amino]-
  • asnuciclib
  • toxicity,Inhibitor,low,AML,Acute,LS 007,myeloid,LS007,leukemia,CLL,Apoptosis,LS-007,endosome,Cyclin dependent kinase,CDKI73,CDKI-73,CDKI 73,inhibit,CDK
  • 3-((5-Fluoro-4-(4-methyl-2-(methylamino)thiazol-5-yl)pyrimidin-2-yl)amino)benzenesulfonamide
  • 3-[[5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-2-pyrimidinyl]amino]-benzenesulfonamide
  • CDKI-73, 10 mM in DMSO
  • Asnuciclib (CDKI-73)
  • CDKI-73 ，S7773
  • 1421693-22-2
  • C15H15FN6O2S2