Kushenol K

Product Name: Kushenol K
CAS No.: 101236-49-1
Chemical Name: Kushenol K
Synonyms: Kushenol K;product/154906;(2R,3S)-2-(2,4-Dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-, (2R,3S)-
CBNumber: CB53034759
Molecular Formula: C26H32O8
Formula Weight: 472.53
MOL File: 101236-49-1.mol

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Kushenol K Property

solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Arctom

Product number: CFN92534
Product name: KushenolK
Purity: ≥98%
Packaging: 5mg
Price: $498
Updated: 2021/12/16

JR MediChem

Product number: JR8-N1216
Product name: KushenolK(NewProduct)
Purity: 98%(HPLC)
Packaging: 5mg
Price: $518
Updated: 2021/12/16

JR MediChem

Product number: JR8-N1216
Product name: KushenolK(NewProduct)
Purity: 98%(HPLC)
Packaging: 10mg
Price: $968
Updated: 2021/12/16

JR MediChem

Product number: JR8-N1216
Product name: KushenolK(NewProduct)
Purity: 98%(HPLC)
Packaging: 20mg
Price: $1980
Updated: 2021/12/16

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Kushenol K Chemical Properties,Usage,Production

Uses

Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM[1]. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM)[2]. Kushenol K also inhibits the activity of SGLT1 and SGLT2[3].

Biological Activity

Kushenol K, a flavonoid antioxidant from Sophora flavescens. It can inhibit the activity of SGLT1 and SGLT2 and used as an inhibitor of CYP3A4 with a Ki value of 1.35 μM.

in vivo

When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC ₅₀ values of 1.62 μM.
At a concentration of 50 μM, the The inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%.

target

PDE

IC 50

CYP3A4: 1.35 μM (Ki); CYP3; SGLT1; SGLT2; HSV-2: 147 μM (EC₅₀)

References

[1] Yannan Li, et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36. DOI:10.1016/j.toxlet.2018.05.008
[2] E R Woo, et al. A new prenylated flavonol from the roots of Sophora flavescens. J Nat Prod. 1998 Dec;61(12):1552-4. DOI:10.1021/np980103j
[3] Seizo Sato, et al. Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9. DOI:10.1016/j.bmc.2007.03.011

Kushenol K Preparation Products And Raw materials

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Preparation Products

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Kushenol K Suppliers

China 39 United States 4 Global 43

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
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Shanghai Aspire Biological Technology Co., Ltd.

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Shanghai Yongye Biotechnology Co., Ltd.

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Wuhan ChemFaces Biochemical Co., Ltd.

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EMMX Biotechnology LLC

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Shanghai ChengShao Biological Technology Co., Ltd.

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Shanghai Yihe Biological Technology Co., Ltd.

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Shanghai Jizhi Biochemical Technology Co. Ltd.

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Chengdu Glip Biotechnology Co., Ltd.

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101236-49-1, Kushenol KRelated Search:

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Kushenol K

(2R,3S)-2-(2,4-Dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-4H-1-benzopyran-4-one

product/154906

4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-, (2R,3S)-

101236-49-1