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Kobophenol A

Product Name: Kobophenol A
CAS No.: 124027-58-3
Chemical Name: Kobophenol A
Synonyms: Kobophenol A;Amobam Impurity 2;(2S,2'R,3S,3'R)-3'-(3,5-Dihydroxyphenyl)-4-[(2S,3S,4R,5S)-4-(3,5-dihydroxyphenyl)tetrahydro-2,5-bis(4-hydroxyphenyl)-3-furanyl]-2,2',3,3'-tetrahydro-2,2'-bis(4-hydroxyphenyl)[3,4'-bibenzofuran]-6,6'-diol;[3,4'-Bibenzofuran]-6,6'-diol, 3'-(3,5-dihydroxyphenyl)-4-[(2S,3S,4R,5S)-4-(3,5-dihydroxyphenyl)tetrahydro-2,5-bis(4-hydroxyphenyl)-3-furanyl]-2,2',3,3'-tetrahydro-2,2'-bis(4-hydroxyphenyl)-, (2S,2'R,3S,3'R)-
CBNumber: CB53037356
Molecular Formula: C56H44O13
Formula Weight: 924.94
MOL File: 124027-58-3.mol

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Kobophenol A Property

Melting point:: 233.5-235 °C (decomp)
Density: 1.497±0.06 g/cm3(Predicted)
storage temp.: 4°C, away from moisture and light
form: Solid
pka: 9.25±0.10(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Arctom

Product number: CFN92530
Product name: KobophenolA
Purity: ≥98%
Packaging: 10mg
Price: $318
Updated: 2021/12/16

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Kobophenol A Chemical Properties,Usage,Production

Uses

Kobophenol A, an oligomeric stilbene, blocks the interaction between the ACE2 receptor and S1-RBD with an IC50 of 1.81 μM and inhibits SARS-CoV-2 viral infection in cells with an EC50 of 71.6 μM. Kobophenol A inhibits the activity of partially purified rat brain protein kinase C (PKC) with an IC50 of 52 μM[1][2].

Biological Activity

References

[1]. Gangadevi S, et al. Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19. J Phys Chem Lett. 2021;12(7):1793-1802. [2]. Xu G, Zhang LP, Chen LF, Hu CQ. Yao Xue Xue Bao. 1994;29(11):818-822.

Kobophenol A Preparation Products And Raw materials

Raw materials

Preparation Products

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124027-58-3, Kobophenol ARelated Search:

Kobophenol A

(2S,2'R,3S,3'R)-3'-(3,5-Dihydroxyphenyl)-4-[(2S,3S,4R,5S)-4-(3,5-dihydroxyphenyl)tetrahydro-2,5-bis(4-hydroxyphenyl)-3-furanyl]-2,2',3,3'-tetrahydro-2,2'-bis(4-hydroxyphenyl)[3,4'-bibenzofuran]-6,6'-diol

[3,4'-Bibenzofuran]-6,6'-diol, 3'-(3,5-dihydroxyphenyl)-4-[(2S,3S,4R,5S)-4-(3,5-dihydroxyphenyl)tetrahydro-2,5-bis(4-hydroxyphenyl)-3-furanyl]-2,2',3,3'-tetrahydro-2,2'-bis(4-hydroxyphenyl)-, (2S,2'R,3S,3'R)-

Amobam Impurity 2

124027-58-3

C56H44O13