3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole

Product Name: 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole
CAS No.: 882697-00-9
Chemical Name: 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole
Synonyms: Anle138b;Emrusolmin;ANLE-138B; ANLE 138B;Anle138b >=98% (HPLC);3-(1,3-Benzodioxol-5-yl)-5-(3-bromophenyl)pyrazole;3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole;1H-Pyrazole, 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-;5-(3-bromophenyl)-3-(3,4-methylenedioxyphenyl)-1H-pyrazole;3-(benzo[d][1,3]dioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole;Inhibitor,Anle138b,penetration,Amyloid-β,pathological,Abeta,β-amyloid peptide,modulator,aggregates,oligomer,Anle-138b,inhibit,degeneration,neuronal
CBNumber: CB53039860
Molecular Formula: C16H11BrN2O2
Formula Weight: 343.17
MOL File: 882697-00-9.mol

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3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole Property

Boiling point:: 527.3±50.0 °C(Predicted)
Density: 1.567±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO (up to 15 mg/ml with warming).
form: powder
pka: 12.57±0.10(Predicted)
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChI: InChI=1S/C16H11BrN2O2/c17-12-3-1-2-10(6-12)13-8-14(19-18-13)11-4-5-15-16(7-11)21-9-20-15/h1-8H,9H2,(H,18,19)
InChIKey: RCQIIBJSUWYYFU-UHFFFAOYSA-N
SMILES: N1C(C2=CC=CC(Br)=C2)=CC(C2=CC=C3OCOC3=C2)=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1515
Product name: Anle138b
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $105
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1515
Product name: Anle138b
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $424
Updated: 2023/06/20

Tocris

Product number: 6861
Product name: Anle138b
Purity: ≥98%(HPLC)
Packaging: 5
Price: $79
Updated: 2021/12/16

Tocris

Product number: 6861
Product name: Anle138b
Purity: ≥98%(HPLC)
Packaging: 25
Price: $309
Updated: 2021/12/16

ChemScene

Product number: CS-6522
Product name: Anle138b
Purity: 99.18%
Packaging: 5mg
Price: $72
Updated: 2021/12/16

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3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole Chemical Properties,Usage,Production

Description

Anle138b (882697-00-9) is an aggregation inhibitor that modulates the formation of pathological oligomers of both prion and α-synuclein.1?In mouse models of prion diseases and Parkinson’s disease, Anle138b strongly inhibited oligomer formation, neuronal degeneration, and disease progression even after disease onset.1,2?Anle138b has delayed disease progression and prevented motor decline in multiple neurodegenerative models.3-6?Treatment of melanoma cells with anle138b caused massive cell death via major dysregulation of autophagy revealing a protective effect of α-synuclein on autophagy in these cells.7?Orally bioavailable and able to cross the blood-brain barrier.

Uses

Anle 138b is an anti-aggregating compound previously shown to delay the onset of scrapie, a transmissible prion disease. A protein aggregation inhibitor.

Biochem/physiol Actions

Anle138b, an oligomer modulator, inhibits neuronal degeneration. It rescues neurons from the aggregation?effects of α-synuclein.

storage

Store at -20°C

References

1) Wagner?et al.?(2013),?Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease;?Acta Neuropathol.,?125?795 2) Levin?et al.?(2014),?The oligomer modulator anle138b inhibits disease progression in a Parkinson’s mouse model even with treatment started after disease onset; Acta Neuropathol.,?127?779 3) Wagner?et al.?(2015),?Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies; Acta Neuropathol.,?130?619 4) Martinez Hernandez?et al.?(2018),?The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology; EMBO Mol. Med.,?10?32 5) Heras-Garvin?et al.?(2019),?Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy; Mov. Disord.,?34?255 6) Brendel?et al.?(2019),?Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau; Alzheimer’s Res. Ther.,?11?67 7) Turriani?et al.?(2017),?Treatment with diphenyl-pyrazole compound anle138b reveals that α-synuclein protects melanoma cells from autophagic cell death; Proc. Natl. Acad. Sci. USA,?114?E4971

3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole Suppliers

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View Lastest Price from 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole 882697-00-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-11-22

Hebei Weibang Biotechnology Co., Ltd

Product: 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole 882697-00-9
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2022-09-21

882697-00-9, 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazoleRelated Search:

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3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole

Anle138b

3-(benzo[d][1,3]dioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole

5-(3-bromophenyl)-3-(3,4-methylenedioxyphenyl)-1H-pyrazole

ANLE-138B; ANLE 138B

1H-Pyrazole, 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-

Anle138b >=98% (HPLC)

Emrusolmin

Inhibitor,Anle138b,penetration,Amyloid-β,pathological,Abeta,β-amyloid peptide,modulator,aggregates,oligomer,Anle-138b,inhibit,degeneration,neuronal

3-(1,3-Benzodioxol-5-yl)-5-(3-bromophenyl)pyrazole

882697-00-9

APIS