Methyl 2-(5-bromopyrimidin-2-yl)acetate
- Product Name
- Methyl 2-(5-bromopyrimidin-2-yl)acetate
- CAS No.
- 948594-80-7
- Chemical Name
- Methyl 2-(5-bromopyrimidin-2-yl)acetate
- Synonyms
- 2-(5-bromopyrimidin-2-yl)acetate;Methyl 2-(5-bromopyrimidin-2-yl);Methyl 5-Bromopyrimidine-2-acetate;6-(Boc-ami)-3-azabicyclo[3.1.1]heptane;Methyl 2-(5-bromopyrimidin-2-yl)acetate;2-Pyrimidineacetic acid, 5-bromo-, methyl ester
- CBNumber
- CB53041140
- Molecular Formula
- C7H7BrN2O2
- Formula Weight
- 231.05
- MOL File
- 948594-80-7.mol
Methyl 2-(5-bromopyrimidin-2-yl)acetate Property
- Boiling point:
- 281.0±20.0 °C(Predicted)
- Density
- 1.594±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -0.53±0.22(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M296963
- Product name
- Methyl2-(5-Bromopyrimidin-2-yl)acetate
- Packaging
- 500mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- 5154AQ
- Product name
- methyl2-(5-bromopyrimidin-2-yl)acetate
- Packaging
- 1g
- Price
- $332
- Updated
- 2021/12/16
- Product number
- 5154AQ
- Product name
- methyl2-(5-bromopyrimidin-2-yl)acetate
- Packaging
- 250mg
- Price
- $161.6
- Updated
- 2021/12/16
- Product number
- HCH0620594
- Product name
- METHYL-2-(5-BROMOPYRIMIDIN-2-YL)ACETATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $450.94
- Updated
- 2021/12/16
- Product number
- 124585
- Product name
- Methyl2-(5-bromopyrimidin-2-yl)acetate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $528
- Updated
- 2021/12/16
Methyl 2-(5-bromopyrimidin-2-yl)acetate Chemical Properties,Usage,Production
Synthesis
948594-79-4
948594-80-7
Step 2: 1-tert-butyl 3-methyl 2-(5-bromopyrimidin-2-yl) malonate (1.88 g, crude) was dissolved in dichloromethane (20 mL). The mixture was cooled to 0 °C, followed by slow dropwise addition of 99% trifluoroacetic acid (10 mL). After the reaction mixture was brought to room temperature, stirring was continued for 4 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. Toluene was added to the residue and the solution was evaporated to dryness. The residue was diluted with ethyl acetate and saturated sodium bicarbonate solution and partitioned. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The crude product was purified by fast column chromatography on silica gel, using a gradient elution of heptane/ethyl acetate (100:0 to 60:40). Fractions containing the target product were collected, combined and concentrated under reduced pressure to give methyl 2-(5-bromopyrimidin-2-yl)acetate (405 mg, 34% yield, calculated in two steps) as a yellow oil.
References
[1] Patent: WO2018/138359, 2018, A1. Location in patent: Page/Page column 41; 64
[2] Patent: WO2007/99335, 2007, A1. Location in patent: Page/Page column 104
[3] Tetrahedron, 2009, vol. 65, # 4, p. 757 - 764
Methyl 2-(5-bromopyrimidin-2-yl)acetate Preparation Products And Raw materials
Raw materials
Preparation Products
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