ChemicalBook > CAS DataBase List > E6446 (dihydrochloride)

E6446 (dihydrochloride)

Product Name: E6446 (dihydrochloride)
CAS No.: 1345675-25-3
Chemical Name: E6446 (dihydrochloride)
Synonyms: CS-2089;E6446 HCl;E6446 2HCl;E-6446 DihydrochL;E6446;E 6446;E-6446;E6446 hydrochloride;E6446 (dihydrochloride);E6446 dihydrochloride, 10 mM in DMSO;E6446 dihydrochloride,E-6446 dihydrochloride;6-(3-(Pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)benzo[d]oxazole dihydrochloride
CBNumber: CB53041403
Molecular Formula: C27H36ClN3O3
Formula Weight: 486.05
MOL File: 1345675-25-3.mol

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E6446 (dihydrochloride) Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO:7.5(Max Conc. mg/mL);14.35(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);38.28(Max Conc. mM)
DMF:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.38(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);3.83(Max Conc. mM)
Water:100.0(Max Conc. mg/mL);191.38(Max Conc. mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

AK Scientific

Product number: 3422DW
Product name: E6446(Dihydrochloride)
Packaging: 2mg
Price: $147
Updated: 2021/12/16

AK Scientific

Product number: 3422DW
Product name: E6446(Dihydrochloride)
Packaging: 1g
Price: $1906
Updated: 2021/12/16

Crysdot

Product number: CD31003814
Product name: E6446dihydrochloride
Purity: 98+%
Packaging: 50mg
Price: $2072
Updated: 2021/12/16

Ambeed

Product number: A119560
Product name: E-6446Dihydrochloride
Purity: 98%
Packaging: 1g
Price: $8397
Updated: 2021/12/16

Arctom

Product number: AS439180
Product name: E-6446Dihydrochloride
Purity: 98%
Packaging: 2mg
Price: $176
Updated: 2021/12/16

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E6446 (dihydrochloride) Chemical Properties,Usage,Production

Uses

E6446 is a synthetic antagonist of nucleic acid-sensing TLRs. , In vitro, low doses of E6446 specifically inhibited the activation of human and mouse TLR9. Tenfold higher concentrations of this compound also inhibited the human TLR8 response to single-stranded RNA. In vivo, therapy with E6446 diminished the activation of TLR9 and prevented the exacerbated cytokine response observed during acute Plasmodium infection. Furthermore, severe signs of ECM, such as limb paralysis, brain vascular leak, and death, were all prevented by oral treatment with E6446.

in vivo

E6446 (20 mg/kg, p.o.) almost cmlpletely inhibits CpG1668-induced IL-6 production, and dose-dependently suppresses the development of ANA (anti-nuclear antibodies) in mice at 20 and 60 mg/kg^[1]. E6446 (20, 60 mg/kg, p.o.) dose-dependently inhibits TLR9 signaling in mice. E6446 (60, 120 mg/kg, p.o.) prevents hyperresponsiveness of TLRs and LPS-induced septic shock in rodent malaria, diminishes TLR responsiveness during acute malaria, suppresses activation of both TLR7 and TLR9^[2].

IC 50

TLR7; TLR9

E6446 (dihydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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E6446 (dihydrochloride) Suppliers

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View Lastest Price from E6446 (dihydrochloride) manufacturers

Career Henan Chemical Co

Product: E6446 (dihydrochloride) 1345675-25-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99。99%
Supply Ability: 200kg
Release date: 2019-12-24

1345675-25-3, E6446 (dihydrochloride)Related Search:

E6446 (dihydrochloride)

E6446 2HCl

E6446 HCl

E6446 hydrochloride

CS-2089

E6446;E 6446;E-6446

E-6446 DihydrochL

6-(3-(Pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)benzo[d]oxazole dihydrochloride

E6446 dihydrochloride,E-6446 dihydrochloride

E6446 dihydrochloride, 10 mM in DMSO

1345675-25-3

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