AZD 3759

ChemicalBook > CAS DataBase List > AZD 3759

Selective EGFR inhibitor

Product Name: AZD 3759
CAS No.: 1626387-80-1
Chemical Name: AZD 3759
Synonyms: azd3579;AZD3759;CS-1596;AZD-3759;AZD 3759;HY-18750;AZD37591;zorifertinib.;zorifertinibum;AZD3759 Powder
CBNumber: CB53041786
Molecular Formula: C22H23ClFN5O3
Formula Weight: 459.9
MOL File: 1626387-80-1.mol

Less

AZD 3759 Property

Boiling point:: 571.4±50.0 °C(Predicted)
Density: 1.358±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥23 mg/mL in DMSO; insoluble in H2O; ≥8.32 mg/mL in EtOH with ultrasonic
form: solid
pka: 6.71±0.40(Predicted)
InChI: InChI=1S/C22H23ClFN5O3/c1-13-11-28(2)7-8-29(13)22(30)32-19-9-14-17(10-18(19)31-3)25-12-26-21(14)27-16-6-4-5-15(23)20(16)24/h4-6,9-10,12-13H,7-8,11H2,1-3H3,(H,25,26,27)/t13-/m1/s1
InChIKey: MXDSJQHFFDGFDK-CYBMUJFWSA-N
SMILES: N1(C(OC2C(OC)=CC3C(C=2)=C(NC2=CC=CC(Cl)=C2F)N=CN=3)=O)CCN(C)C[C@H]1C

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 19931
Product name: AZD 3759
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19931
Product name: AZD 3759
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 19931
Product name: AZD 3759
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

Cayman Chemical

Product number: 19931
Product name: AZD 3759
Purity: ≥98%
Packaging: 25mg
Price: $343
Updated: 2024/03/01

TRC

Product number: A808165
Product name: AZD3759
Packaging: 25mg
Price: $170
Updated: 2021/12/16

Less

AZD 3759 Chemical Properties,Usage,Production

Selective EGFR inhibitor

AZD3759 is a selective EGFR inhibitor that can fully penetrate the blood-brain barrier (BBB), with equal free concentrations in the blood, cerebrospinal fluid, and brain tissue. Treatment with AZD3759 causes tumor regression in subcutaneous xenograft, leptomeningeal metastasis (LM), and brain metastasis (BM) lung cancer models and prevents the development of BM in nude mice.

Description

AZD3759 is an EGFP inhibitor (Epidermal growth factor receptor tyrosine kinase inhibitor) with blood brain barrier (BBB) penetration. It has the potential for the treatment of non-small cell lung cancer (NSCLC), with brain metastases (BM) and leptomengingeal metastases (LM) since this type of cancer often contain a lot of activating mutations of the epidermal growth factor receptor (EGFR). It has excellent capability of penetrating the blood brain barrier to reach the central nervous system.

Uses

AZD 3759 is EGFR inhibitor. It is a potent, oral active, central nervous system-penetrant, epidermal growth factor receptor tyrosine kinase inhibitor.

References

Zeng, Qingbei, et al. "Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR TKI)." Journal of Medicinal Chemistry 58.20(2015):8200.
Yang, Zhenfan, et al. "Abstract LB-217: Antitumor activities of AZD3759, a novel EGFR inhibitor with excellent penetration across central nervous system (CNS), in preclinical animal models." Cancer Research 76.14 Supplement(2016):LB-217-LB-217.
Xiong, S., et al. "Determination of AZD3759 in rat plasma and brain tissue by LC-MS/MS and its application in pharmacokinetic and brain distribution studies." Journal of Pharmaceutical & Biomedical Analysis140(2017):362-366.

AZD 3759 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

AZD 3759 Suppliers

China 246 India 1 United States 13 Global 260

Jinan Chuanbei Biotechnology Co., Ltd

Tel: 15269175648
Fax: 0531-67802093
Email: qingyan7590@163.com
Country: China
ProdList: 20
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6010
Advantage: 61

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 17702719238
Email: sales@sun-shinechem.com
Country: China
ProdList: 918
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 18089
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-021-64543801 13764082696
Email: 2355241799@qq.com
Country: China
ProdList: 42982
Advantage: 64

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4663
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9449
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7854
Advantage: 58

DONGSHENG CHIRAL PHARMA

Tel: 180000000
Email: 3755454181@qq.com
Country: China
ProdList: 419
Advantage: 55

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3423
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9634
Advantage: 58

Shanghai CanSpecsci Instrument Co., Ltd.

Tel: 400-6087598 15021221957
Fax: 4006087598-8012
Email: order@canspecsci.com
Country: China
ProdList: 2071
Advantage: 56

Jinan Cheminn Chemicals Co., Ltd.

Tel: 531-67875205 15726170169
Fax: +86-531-67875205
Email: sales@cheminn.com
Country: China
ProdList: 60
Advantage: 60

HangZhou YuHao Chemical Technology Co., Ltd.

Tel: 0571-82693216
Fax: 0571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 2031
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2989
Advantage: 60

Hunan Cangood Medical Technology Ltd.

Tel: 400-026-9899
Fax: +86-731-86905278
Country: China
ProdList: 71
Advantage: 50

Hefei NaNo Biological Technology Co., Ltd.

Tel: 0551-65629887 18010855303
Fax: 0551-65629887
Email: sales@hfnhsw.com
Country: China
ProdList: 262
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4153
Advantage: 55

Watson Biotechnology Co.,Ltd

Tel: 027-027-59207879 18140587686
Fax: QQ：1972026995
Email: kf@3600chem.com
Country: China
ProdList: 4697
Advantage: 55

Nanjing Chempioneer Pharmaceutical Co., Ltd.

Tel: 18068075658
Fax: -
Email: sales@chempioneer.com
Country: China
ProdList: 1811
Advantage: 58

D&C Chemicals

Tel: +86-21-58447131
Fax: +86-21-61642470
Email: 1724405207@qq.com
Country: China
ProdList: 472
Advantage: 55

Yangzhou QinYuan Pharmaceutical Co., Ltd.

Tel: 0514-80939770 13773367191
Fax: 0514-82664689
Email: yzqyyykj@163.com
Country: China
ProdList: 228
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 316
Advantage: 55

Biyu Biotechnology (Shanghai) Co., ltd

Tel: 021-26018599
Country: China
ProdList: 270
Advantage: 56

Shanghai Send Pharmaceutical Technology Co., Ltd.

Tel: 021-58088081 Q3382968513
Fax: QQ3382968513
Email: hailey@shsendpharm.com
Country: China
ProdList: 3151
Advantage: 55

shandong XuanHong Pharmaceutical Technology Co.,Ltd

Tel: 0531-88801869 15562622698
Fax: 0531-88801867
Email: sciencechem@163.com
Country: China
ProdList: 275
Advantage: 55

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9638
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: 3429815786 13301662590
Fax: +86-21-51619052
Email: sales@atkchemical.com
Country: China
ProdList: 10005
Advantage: 55

Nanjing XiLang Chemical Products Co., Ltd.

Tel: 025-5276156 18936048580
Email: chemxilang@163.com
Country: China
ProdList: 4009
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3868
Advantage: 58

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9934
Advantage: 55

Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 021-021-20242659 18930833303
Fax: +86 (21) 2024-2659
Email: order@changyanchem.com
Country: China
ProdList: 5008
Advantage: 55

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9604
Advantage: 55

Cangzhou Enke Pharma-tech Co., Ltd.

Tel: 0317-5296180 15533709196
Fax: 0317-5106596
Email: sale@enkepharma.com
Country: China
ProdList: 1647
Advantage: 55

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2993
Advantage: 58

Grader reagent

Tel: 18221735425
Email: sales@xinpingchem.com
Country: China
ProdList: 9951
Advantage: 58

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 5477
Advantage: 58

Jinan elephant international trading co., LTD

Tel
Fax: -
Email: 13006575422@163.com
Country: China
ProdList: 6357
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9767
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 9859
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29796
Advantage: 68

Hubei widely chemical technology Co., Ltd.

Tel: 027-83991130 18627774460
Fax: 027-83991130
Email: 1718093273@QQ.COM
Country: China
ProdList: 1891
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
Advantage: 58

Less

View Lastest Price from AZD 3759 manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: AZD3759 1626387-80-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-09

Handan Tongyi New Material Technology Co., Ltd

Product: AZD 3759 1626387-80-1
Price: US $100.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99.9%
Supply Ability: 800kgs/month
Release date: 2021-03-09

Hebei Zhanyao Biotechnology Co. Ltd

Product: AZD3759 Powder 1626387-80-1
Price: US $50.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10000 kg
Release date: 2021-08-18

1626387-80-1, AZD 3759Related Search:

Canagliflozin AZD-4547 Alectinib WZ4002 lenvatinib Mesylate Lenvatinib BKM-120 Olmutinib XL-647 Genistein AG 1478 HYDROCHLORIDE OSI-420 Anlotinib EGF816 Tucatinib Neratinib Poziotinib (HM781-36B) CO-1686

AZD 3759

AZD3759

AZD-3759

(2R)-2,4-Dimethyl-1-piperazinecarboxylic acid 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester

HY-18750

azd3579

1-Piperazinecarboxylic acid, 2,4-dimethyl-, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester, (2R)-

1-PIPERAZINECARBOXYLIC ACID, 2,4-DIMETHYL-, 4-[(3-CHLORO-2-FLUOROPHENYL)AMINO]-7-METHOXY-6-QUINAZOLINYL ESTER

4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl (2R)-2,4-dimethylpiperazine-1-carb

(R)-4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate

zorifertinibum

AZD3759; AZD-3759; AZD 3759; ZORIFERTINIBUM; ZORIFERTINIB.

zorifertinib.

4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl 1-piperazinecarboxylic acid 2,4-dimethyl ester

4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl (2R)-2,4-dimethylpiperazine-1-carboxylate

CS-1596

AZD-3759;AZD 3759;;AZD3759

AZD37591

4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl (R)-2,4-dimethylpiperazine-1-carboxylate

High Purity Azd 3759 CAS:

High Purity Azd3759/Azd-3759 CAS 1626387-80-1 with Steady Supply

Anti Cancer Azd3759, High Purity

AZD3759 Powder

Zorifertinib (AZD3759

TIANFU CHEM---AZD 3759

4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl (2R)-2,4-dimethyl-1-piperazinecarboxylate

AZD3759 AZD-3759

1626387-80-1

626387-80-1

C22H23ClFN5O3

API