ChemicalBook > CAS DataBase List > Nampt-IN-1

Nampt-IN-1

Product Name
Nampt-IN-1
CAS No.
1698878-14-6
Chemical Name
Nampt-IN-1
Synonyms
LSN3154567;Nampt-IN-1;Nampt inhibitor 1;LSN3154567 (Nampt-IN-1);LSN 3154567;LSN-3154567;LSN3154567;2-hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-;2-Hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-isoquinolinyl]-1-propanesulfonamide;2-hydroxy-2-methyl-N-(2-(2-(pyridin-3-yloxy)acetyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)propane-1-sulfonamide;1-Propanesulfonamide, 2-hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-isoquinolinyl]-;LSN-3154567,NAMPT,PBEF,Nampt IN 1,Visfatin,inhibit,Pre-B cell colony enhancing factor,Nicotinamide phosphoribosyl transferase,Inhibitor,NamptIN1,LSN 3154567
CBNumber
CB53048664
Molecular Formula
C20H25N3O5S
Formula Weight
419.49
MOL File
1698878-14-6.mol
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Nampt-IN-1 Property

Boiling point:
659.9±65.0 °C(Predicted)
Density 
1.363±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: Soluble
form 
powder
pka
8.67±0.20(Predicted)
color 
white to beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2249
Product name
LSN3154567
Purity
≥98% (HPLC)
Packaging
5mg
Price
$107
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2249
Product name
LSN3154567
Purity
≥98% (HPLC)
Packaging
25mg
Price
$430
Updated
2024/03/01
Cayman Chemical
Product number
26066
Product name
Nampt-IN-1
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
26066
Product name
Nampt-IN-1
Purity
≥98%
Packaging
5mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
26066
Product name
Nampt-IN-1
Purity
≥98%
Packaging
10mg
Price
$321
Updated
2024/03/01
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Nampt-IN-1 Chemical Properties,Usage,Production

Description

Nampt-IN-1 is a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt; IC50 = 3.1 nM). It is selective for Nampt over a panel of greater than 100 human kinases at 1 μM. Nampt-IN-1 inhibits NAD+ formation in and proliferation of HCT116 cells (IC50s = 1.8 and 8.9 nM, respectively). It inhibits cell growth in a panel of cancer cell lines (IC50s = <0.2-2 μM). Nampt-IN-1 inhibits NAD+ formation in an A2780 ovarian carcinoma mouse xenograft model (ED50 = 2 mg/kg).

Uses

Nampt-IN-1 functions as a co-drug. Nampt-IN-1 is a potent and selective NAMPT inhibitor.

Biochem/physiol Actions

LSN3154567 might be useful in developing a novel cancer therapeutic.

Nampt-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Nampt-IN-1 Suppliers

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1698878-14-6, Nampt-IN-1Related Search:

N-Methyldiethanolamine N-Methylbenzylamine 2-Methylaminoethanol N-Methylbenzamide 2,2-DIMETHYLTETRAHYDROFURAN

  • Nampt-IN-1
  • 2-hydroxy-2-methyl-N-(2-(2-(pyridin-3-yloxy)acetyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)propane-1-sulfonamide
  • 2-Hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-isoquinolinyl]-1-propanesulfonamide
  • LSN3154567 (Nampt-IN-1)
  • LSN3154567
  • 2-hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-
  • LSN 3154567;LSN-3154567;LSN3154567
  • Nampt inhibitor 1
  • 1-Propanesulfonamide, 2-hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-isoquinolinyl]-
  • LSN-3154567,NAMPT,PBEF,Nampt IN 1,Visfatin,inhibit,Pre-B cell colony enhancing factor,Nicotinamide phosphoribosyl transferase,Inhibitor,NamptIN1,LSN 3154567
  • 1698878-14-6