4-bromo-N'-butylbenzohydrazide

ChemicalBook > CAS DataBase List > 4-bromo-N'-butylbenzohydrazide

4-bromo-N'-butylbenzohydrazide

Product Name: 4-bromo-N'-butylbenzohydrazide
CAS No.: 537672-41-6
Chemical Name: 4-bromo-N'-butylbenzohydrazide
Synonyms: UF 010;CS-2427;UF010, >98%;UF-010; UF 010;UF010 >=98% (HPLC);4-Bromo-N'-butylbenzohydrazide;4-bromo-N'-butylbenzohydrazide;4-Bromobenzoic acid 2-butylhydrazide;Benzoic acid, 4-bromo-, 2-butylhydrazide;UF010,HDAC,UF-010,UF 010,Histone deacetylases,Inhibitor,inhibit
CBNumber: CB53049247
Molecular Formula: C11H15BrN2O
Formula Weight: 271.15
MOL File: 537672-41-6.mol

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4-bromo-N'-butylbenzohydrazide Property

storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: insoluble in H2O; ≥10.65 mg/mL in DMSO; ≥20.85 mg/mL in EtOH
form: solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21273
Product name: UF010
Purity: ≥98%
Packaging: 5mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 21273
Product name: UF010
Purity: ≥98%
Packaging: 10mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 21273
Product name: UF010
Purity: ≥98%
Packaging: 25mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 21273
Product name: UF010
Purity: ≥98%
Packaging: 50mg
Price: $321
Updated: 2024/03/01

TRC

Product number: B680880
Product name: 4-Bromo-2-butylhydrazideBenzoicAcid
Packaging: 25mg
Price: $165
Updated: 2021/12/16

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4-bromo-N'-butylbenzohydrazide Chemical Properties,Usage,Production

Description

UF010 is a class I HDAC inhibitor with IC₅₀ values of 0.06, 0.1, 0.5, and 1.5 μM for HDAC3, 2, 1, and 8, respectively. It is more than 6-fold selective for these class I HDACs over any additional HDACs. UF010 is reported to inhibit cancer cell proliferation with a mean GI₅₀ value of 2.94 μM when screened against the NCI-60 panel of cancer cell lines and functions by blocking the G₁/S phase of the cell cycle.

Uses

4-Bromo-2-butylhydrazide Benzoic Acid inhibits histone deacetylases (HDAC) as potential clinical anticancer therapies.

References

[1]. wang y, stowe rl, pinello ce, et al. identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class i histone deacetylases. chem biol, 2015, 22(2): 273-284.

4-bromo-N'-butylbenzohydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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537672-41-6, 4-bromo-N'-butylbenzohydrazideRelated Search:

4-bromo-N'-butylbenzohydrazide

UF 010

4-Bromobenzoic acid 2-butylhydrazide

CS-2427

UF-010; UF 010

UF010, >98%

Benzoic acid, 4-bromo-, 2-butylhydrazide

UF010 >=98% (HPLC)

UF010,HDAC,UF-010,UF 010,Histone deacetylases,Inhibitor,inhibit

4-Bromo-N'-butylbenzohydrazide

537672-41-6