ChemicalBook > CAS DataBase List > DASA-58

DASA-58

Product Name
DASA-58
CAS No.
1203494-49-8
Chemical Name
DASA-58
Synonyms
DASA-58;CS-1563;DASA58; DASA 58;3-[[4-[(2,3-Dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]benzenamine;Benzenamine, 3-[[4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]-;DASA58,inhibit,Inhibitor,DASA 58,DASA-58,glycolysis,TXNIP,cancer metabolism,Pyruvate Kinase,pyruvate kinase M2,breast cancer,AMPK
CBNumber
CB53049409
Molecular Formula
C19H23N3O6S2
Formula Weight
453.53
MOL File
1203494-49-8.mol
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DASA-58 Property

Boiling point:
681.5±65.0 °C(Predicted)
Density 
1.453±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
insoluble in EtOH; insoluble in H2O; ≥127.2 mg/mL in DMSO
form 
solid
pka
3.35±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2853
Product name
DASA-58
Purity
≥98% (HPLC)
Packaging
5MG
Price
$94.2
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2853
Product name
DASA-58
Purity
≥98% (HPLC)
Packaging
25MG
Price
$306
Updated
2024/03/01
Cayman Chemical
Product number
13941
Product name
DASA-58
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
13941
Product name
DASA-58
Purity
≥98%
Packaging
5mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
13941
Product name
DASA-58
Purity
≥98%
Packaging
10mg
Price
$321
Updated
2024/03/01
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DASA-58 Chemical Properties,Usage,Production

Description

DASA-58 is a selective activator of pyruvate kinase M2 (PKM2; AC50 = 38 nM in vitro, EC50 = 19.6 μM in cells). DASA-58 converts PKM2 to a constitutively active enzyme state that is resistant to inhibition by tyrosine-phosphorylated proteins. Through its effects on PKM2, DASA-58 blocks the induction of HIF-1α by lipopolysaccharide in bone marrow-derived macrophages, suppressing the expression of several HIF-1α-dependent targets, including IL-1β. It also impairs metastatic dissemination of prostate cancer PCa cells in SCID mice.

Definition

ChEBI: 3-[[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1,4-diazepan-1-yl]sulfonyl]aniline is a member of benzenes and a sulfonamide.

References

[1]. anastasiou d, yu y, israelsen wj, et al. pyruvate kinase m2 activators promote tetramer formation and suppress tumorigenesis. nature chemical biology, 2012, 8(10): 839-847.

DASA-58 Preparation Products And Raw materials

Raw materials

Preparation Products

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DASA-58 Suppliers

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1203494-49-8, DASA-58Related Search:


  • DASA-58
  • 3-[[4-[(2,3-Dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]benzenamine
  • DASA58; DASA 58
  • CS-1563
  • Benzenamine, 3-[[4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]-
  • DASA58,inhibit,Inhibitor,DASA 58,DASA-58,glycolysis,TXNIP,cancer metabolism,Pyruvate Kinase,pyruvate kinase M2,breast cancer,AMPK
  • 1203494-49-8