3,4-dichloro-2-iodobenzenamine
- Product Name
- 3,4-dichloro-2-iodobenzenamine
- CAS No.
- 835595-11-4
- Chemical Name
- 3,4-dichloro-2-iodobenzenamine
- Synonyms
- 177302;3,4-Dichloro-2-iodoaniline;3,4-dichloro-2-iodobenzenamine;Benzenamine, 3,4-dichloro-2-iodo-
- CBNumber
- CB53053950
- Molecular Formula
- C6H4Cl2IN
- Formula Weight
- 287.91
- MOL File
- 835595-11-4.mol
3,4-dichloro-2-iodobenzenamine Property
- Melting point:
- 40 °C
- Boiling point:
- 335.7±42.0 °C(Predicted)
- Density
- 2.091±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 0.84±0.10(Predicted)
- Appearance
- Light brown to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 2646AQ
- Product name
- 3,4-DICHLORO-2-IODOANILINE
- Packaging
- 1g
- Price
- $525.2
- Updated
- 2021/12/16
- Product number
- A233249
- Product name
- 3,4-Dichloro-2-iodoaniline
- Purity
- 95%
- Packaging
- 5g
- Price
- $631
- Updated
- 2021/12/16
- Product number
- CM255225
- Product name
- 3,4-Dichloro-2-iodoaniline
- Purity
- 95%
- Packaging
- 5g
- Price
- $748
- Updated
- 2021/12/16
- Product number
- CD12026777
- Product name
- 3,4-Dichloro-2-iodoaniline
- Purity
- 95%
- Packaging
- 5g
- Price
- $792
- Updated
- 2021/12/16
- Product number
- 835595114
- Product name
- 3,4-Dichloro-2-iodoaniline
- Packaging
- 5g
- Price
- $800
- Updated
- 2021/12/16
3,4-dichloro-2-iodobenzenamine Chemical Properties,Usage,Production
Synthesis
95-76-1
835595-11-4
The general procedure for the synthesis of 3,4-dichloro-2-iodoaniline from 3,4-dichloroaniline was as follows: to a stirred suspension of 3,4-dichloroaniline (20 g, 123 mmol), hydriodic acid (48%, 15.7 g, 123 mmol), and hydrogen peroxide (30%, 8.3 g, 246 mmol) in water (62 mL) at 37 °C. The reaction mixture was stirred overnight at room temperature protected from light. Upon completion of the reaction, the supernatant was discarded, the reaction mixture was diluted with ethyl acetate:hexane (1:10), quenched with saturated sodium bisulfite solution, stirred at ambient temperature for 1 h. The solid was collected by filtration. The filtrate was washed sequentially with water and saturated aqueous sodium bicarbonate solution, dried over anhydrous sodium sulfate, filtered and concentrated to give a mixture of 1:4 regional isomers of the iodo derivative (the primary target being the secondary isomer). The mixture was recrystallized from cyclohexane to give a 1:1 mixture of regional isomers enriched in the filtrate. The mixture was further purified by silica gel fast column chromatography using ethyl acetate:hexane (0-2%) gradient elution to afford the target compound 3,4-dichloro-2-iodoaniline as a cream-colored solid (5.2 g, ~15% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.22 (d, J=8.6 Hz, 1H), 6.60 (d, J=8.6 Hz, 1H), 4.32 (br, 2H).
References
[1] Patent: WO2015/84842, 2015, A1. Location in patent: Paragraph 0092
3,4-dichloro-2-iodobenzenamine Preparation Products And Raw materials
Raw materials
Preparation Products
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