Boc-Gly-Gly-OSu
- Product Name
- Boc-Gly-Gly-OSu
- CAS No.
- 29248-48-4
- Chemical Name
- Boc-Gly-Gly-OSu
- Synonyms
- Boc-Gly-Gly-NHSE;Boc-Gly-Gly-NHS ester;Nalpha-Boc-glycyl-glycine N-Hydroxysuccinimide Ester;Glycine, N-[(1,1-dimethylethoxy)carbonyl]glycyl-, 2,5-dioxo-1-pyrrolidinyl ester;(2,5-dioxopyrrolidin-1-yl) 2-[[2-[(2-methylpropan-2-yl)oxycarbonylamino]acetyl]amino]acetate
- CBNumber
- CB53054508
- Molecular Formula
- C13H19N3O7
- Formula Weight
- 329.31
- MOL File
- 29248-48-4.mol
Boc-Gly-Gly-OSu Property
- Melting point:
- 159-161 °C(Solv: isopropanol (67-63-0))
- Density
- 1.34±0.1 g/cm3(Predicted)
- solubility
- Soluble in DMSO, DCM, DMF
- pka
- 11.18±0.46(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BP-24526
- Product name
- Boc-Gly-Gly-NHSester
- Purity
- 96%
- Packaging
- 500mg
- Price
- $650
- Updated
- 2021/12/16
- Product number
- CM251969
- Product name
- Boc-Gly-Gly-OSU
- Purity
- 97%
- Packaging
- 10g
- Price
- $133
- Updated
- 2021/12/16
Boc-Gly-Gly-OSu Chemical Properties,Usage,Production
Synthesis
6066-82-6
31972-52-8
29248-48-4
GENERAL STEPS: Boc-glycylglycine (1.00 g, 7.57 mmol) was dissolved in a solvent mixture of dioxane and water (30:5 mL) at room temperature, and triethylamine (1.15 g, 11.4 mmol) and di-tert-butyl dicarbonate (1.84 g, 8.33 mmol) were added sequentially. The reaction mixture was stirred overnight at room temperature, then diluted with water, the pH was adjusted to about 2 by addition of solid KHSO4, extracted with EtOAc, and the organic phase was dried with anhydrous Na2SO4 and concentrated under reduced pressure to give (tert-butoxycarbonyl)glycylglycine [8] as a white solid. The crude (tert-butoxycarbonyl)glycylglycine (0.106 g, 0.451 mmol) was dissolved in anhydrous dichloromethane (5.00 mL) and triethylamine (45.6 mg, 0.451 mmol) and propylphosphinic anhydride (T3P) [9] (0.344 g, 0.541 mmol) solution was added. The mixture was stirred at room temperature for 20 min before N-hydroxysuccinimide (51.9 mg, 0.451 mmol) was added. The reaction was continued to stir for 48 h. Upon completion, the organic layer was washed with brine (3 times), dried over anhydrous Na2SO4 and concentrated under reduced pressure to give the crude product as a white solid. The crude product was purified by ether milling to afford 65.4 mg (44% yield) of the target compound 2,5-dioxopyrrolidin-1-yl 2-(2-((tert-butoxycarbonyl)amino)acetylamino)acetate as a white solid: 1H NMR (400 MHz, CDCl3) δ 6.76 (brs, 1H), 5.15 (brs, 1H), 4.43 (d , 2H, J = 5.7 Hz), 3.87 (d, 2H, J = 5.3 Hz), 2.85 (s, 4H), 1.45 (s, 9H); ESI-MS m/z 330 [M+H]+. The elemental composition of the products was confirmed to be within 5 ppm error by high-resolution accurate mass measurements (Exactive Plus, Thermo Fisher Scientific) in negative ion mode by direct injection into ESI-MS (see Fig. 1).
References
[1] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 22, p. 5973 - 5982
[2] Journal of Pharmaceutical Sciences, 1984, vol. 73, # 2, p. 275 - 277
[3] Analytical Biochemistry, 2016, vol. 512, p. 114 - 119
Boc-Gly-Gly-OSu Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Boc-Gly-Gly-OSu manufacturers
- Product
- Boc-Gly-Gly-OSu 29248-48-4
- Price
- US $6.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-28