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XEN907

Product Name
XEN907
CAS No.
912656-34-9
Chemical Name
XEN907
Synonyms
XEN907;XEN907,XEN-907;XEN907, 10 mM in DMSO;XEN907; XEN 907; XEN-907;1'-pentylspiro[6H-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;1-Pentyl-6'H-spiro[indoline-3,7'-[1,3]dioxolo[4,5-f]benzofuran]-2-one;1-Pentyl-6'H-spiro[indoline-3,7'-[1,3]dioxolo[4,5-f]benzofuran]-2-one;Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3'-[3H]indol]-2'(1'H)-one, 1'-pentyl-;1-CYCLOPENTYL-1,2-DIHYDRO-6',10',12'-TRIOXASPIRO[INDOLE-3,4'-TRICYCLO[7.3.0.0^{3,7}]DODECANE]-1',3'(7'),8'-TRIEN-2-ONE
CBNumber
CB53060912
Molecular Formula
C21H21NO4
Formula Weight
351.4
MOL File
912656-34-9.mol
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XEN907 Property

Melting point:
88-90 °C
Boiling point:
566.9±50.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
-0.19±0.20(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5482
Product name
XEN907
Purity
99.55%
Packaging
5mg
Price
$150
Updated
2021/12/16
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XEN907 Chemical Properties,Usage,Production

Description

XEN907 is a novel spirooxindole NaV1.7 blocker with IC50 of 3 nM. It shows a further 10-fold increase in potency, which represents a promising structure for further optimization efforts in vitro.

Uses

XEN907 is a potent and spirooxindole blocker of NaV1.7, with an IC50 of 3 nM. XEN907 also inhibits CYP3A4 in a recombinant human enzyme assay. XEN907 can be used for the research of pain[1][2].

in vivo

XEN907 (10 mg/kg; p.o.) exhibits moderate oral bioavailability (13 %), Cmax (35 ng/mL), and AUClast (143 h?ng/mL) in rats[1].
XEN907 (3 mg/kg; i.v.) exhibits terminal elimination half-life (2.6 h), high plasma clearance (9.4 L/h/kg), and large volumes of distribution (35.0 L/kg) in rats[1].

IC 50

Nav1.7

References

[1] Chowdhury S, et al. Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3676-81. DOI:10.1016/j.bmcl.2011.04.088
[2] Chowdhury S, et, al. Tetracyclic spirooxindole blockers of hNaV1.7: activity in vitro and in CFA-induced inflammatory pain model. Med Chem Res (2013) 22:1825–1836.

XEN907 Preparation Products And Raw materials

Raw materials

Preparation Products

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XEN907 Suppliers

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WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
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912656-34-9, XEN907Related Search:

10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE XENOLIGHT D-LUCIFERIN POTASSIUM SALT

  • XEN907
  • 1-CYCLOPENTYL-1,2-DIHYDRO-6',10',12'-TRIOXASPIRO[INDOLE-3,4'-TRICYCLO[7.3.0.0^{3,7}]DODECANE]-1',3'(7'),8'-TRIEN-2-ONE
  • XEN907; XEN 907; XEN-907
  • Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3'-[3H]indol]-2'(1'H)-one, 1'-pentyl-
  • 1'-pentylspiro[6H-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one
  • XEN907,XEN-907
  • 1-Pentyl-6'H-spiro[indoline-3,7'-[1,3]dioxolo[4,5-f]benzofuran]-2-one
  • XEN907, 10 mM in DMSO
  • 1-Pentyl-6'H-spiro[indoline-3,7'-[1,3]dioxolo[4,5-f]benzofuran]-2-one
  • 912656-34-9