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Naquotinib

Product Name
Naquotinib
CAS No.
1448232-80-1
Chemical Name
Naquotinib
Synonyms
ASP-8273;Naquotinib;Naquotinib,ASP-8273;NAQUOTINIB (FREE BASE);Epidermal growth factor receptor,EGFR,ASP 8273,HER1,ErbB-1,ASP-8273,inhibit,Naquotinib,Inhibitor;(R)-5-((1-acryloylpyrrolidin-3-yl)oxy)-6-ethyl-3-((4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrazine-2-carboxamide;6-Ethyl-3-[[4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[[(3R)-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl]oxy]-2-pyrazinecarboxamide;2-Pyrazinecarboxamide, 6-ethyl-3-[[4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[[(3R)-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl]oxy]-
CBNumber
CB53062789
Molecular Formula
C30H42N8O3
Formula Weight
562.71
MOL File
1448232-80-1.mol
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Naquotinib Property

Boiling point:
717.6±60.0 °C(Predicted)
Density 
1.248±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 30mg/ml; DMSO: 2 mg/ml; Ethanol: 30mg/ml
form 
A crystalline solid
pka
14.10±0.50(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23498
Product name
Naquotinib
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
23498
Product name
Naquotinib
Purity
≥98%
Packaging
5mg
Price
$151
Updated
2024/03/01
Cayman Chemical
Product number
23498
Product name
Naquotinib
Purity
≥98%
Packaging
10mg
Price
$278
Updated
2024/03/01
TRC
Product number
N378710
Product name
Naquotinib
Packaging
1mg
Price
$80
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611431
Product name
Naquotinib
Packaging
5mg
Price
$569.5
Updated
2021/12/16
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Naquotinib Chemical Properties,Usage,Production

Uses

Naquotinib is an epidermal growth factor receptor (EGFR) inhibitor.

Biological Activity

Naquotinib (ASP8273) is an orally active, irreversible, mutant-selective epidermal growth factor receptor (EGFR) inhibitor with potential antitumor activity.

in vitro

ASP8273 is an irreversible TKI small molecule inhibitor that inhibits the kinase activity of EGFR mutants including T97M with limited activity against wild-type EGFR. In in vitro enzymatic activity and cellular assays, ASP8273 covalently bound to an EGFR mutant (L858R/T790M) through cysteine residues and long-term inhibited EGFR phosphorylation for 24 hours. In NSCLC cell lines with the above-mentioned EGFR mutations, ASP8273 has IC50 values in the range of 8-33 nM for EGFR mutants, more potent than WT EGFR (IC50 for WT EGFR is 230 nM).

target

TargetValue
mutant EGFR

Naquotinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Naquotinib Suppliers

China 46 India 1 United States 7 Global 54
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58

1448232-80-1, NaquotinibRelated Search:


  • Naquotinib
  • ASP-8273
  • 6-Ethyl-3-[[4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[[(3R)-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl]oxy]-2-pyrazinecarboxamide
  • (R)-5-((1-acryloylpyrrolidin-3-yl)oxy)-6-ethyl-3-((4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrazine-2-carboxamide
  • Naquotinib,ASP-8273
  • NAQUOTINIB (FREE BASE)
  • 2-Pyrazinecarboxamide, 6-ethyl-3-[[4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[[(3R)-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl]oxy]-
  • Epidermal growth factor receptor,EGFR,ASP 8273,HER1,ErbB-1,ASP-8273,inhibit,Naquotinib,Inhibitor
  • 1448232-80-1
  • 448232-80-1