Bizine Dihydrochloride
- Product Name
- Bizine Dihydrochloride
- CAS No.
- 1591932-50-1
- Chemical Name
- Bizine Dihydrochloride
- Synonyms
- Bizine;Bizine Dihydrochloride;N-[4-(2-hydrazinylethyl)phenyl]-benzenebutanamide;Benzenebutanamide, N-[4-(2-hydrazinylethyl)phenyl]-
- CBNumber
- CB53067537
- Molecular Formula
- C18H23N3O
- Formula Weight
- 297.39
- MOL File
- 1591932-50-1.mol
Bizine Dihydrochloride Property
- Boiling point:
- 566.5±50.0 °C(Predicted)
- Density
- 1.137±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤25mg/ml in DMSO;20mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 14.88±0.70(Predicted)
N-Bromosuccinimide Price
- Product number
- 19705
- Product name
- Bizine
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 19705
- Product name
- Bizine
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 19705
- Product name
- Bizine
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $188
- Updated
- 2024/03/01
- Product number
- C5162
- Product name
- Bizine
- Packaging
- 10mg
- Price
- $192
- Updated
- 2021/12/16
- Product number
- Axon 2306
- Product name
- Bizine
- Purity
- 98%
- Packaging
- 2x10mg
- Price
- $198
- Updated
- 2021/12/16
Bizine Dihydrochloride Chemical Properties,Usage,Production
Uses
Bizine Dihydrochloride is a potent LSD1 inhibitor in vitro, being selective versus monoamine oxidases A/B and the LSD1 homologue, LSD2.
Biological Activity
ki(inact) = 59 nmbizine is a lsd1 inhibitor.lysine-specific demethylase 1 (lsd1), an epigenetic enzyme, can oxidatively cleave methyl groups from monomethyl and dimethyl lys4 of histone h3 and can also contribute to gene silencing.
in vitro
in a previous study, bizine, a novel phenelzine analogue with a phenyl-butyrylamide appendage, was foundto be a potent in vitro lsd1 inhibitor and was selective against monoamine oxidases a/b and lsd2, the lsd1 homologue. moreover, in cancer cells, bizine was shown to be effective at modulating bulk histone methylation and the chip-seq experiment demonstrated a statistically significant overlap in the h3k4 methylation pattern of genes affected by bizine and those altered in lsd1-/- cells. in addition, the treatment of two cancer cell lines, lncap and h460, with bizine led to a reduction in proliferation rate, and bizine also showed additive to synergistic effects on cell growth when used in combination with two tested hdac inhibitors. furthermore, neurons exposed to oxidative stress could be protected by the treatment of bizine, indicating its potential applications in neurodegenerative disease [1].
References
[1] prusevich, p. ,kalin, j.h.,ming, s.a., et al. a selective phenelzine analogue inhibitor of histone demethylase lsd1. acs chem biol. 9, 1284-1293 (2014).
Bizine Dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Bizine Dihydrochloride Suppliers
- Tel
- +86-400-851-9921
- Fax
- +86-10-82826195
- sales@pharmacodia.com
- Country
- China
- ProdList
- 2317
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9804
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 86-(0)29-85992781 17792393971
- info@lynnchem.com
- Country
- China
- ProdList
- 4587
- Advantage
- 58
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58
- Tel
- 86-571-88216897,88216896 13588875226
- Fax
- 86-571-88216895
- sales@hzclap.com
- Country
- CHINA
- ProdList
- 6312
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 0519-85524369
- 3477467573@qq.com
- Country
- China
- ProdList
- 8617
- Advantage
- 58
- Tel
- 15865264761
- 486064515@qq.com
- Country
- China
- ProdList
- 4993
- Advantage
- 58