ChemicalBook > CAS DataBase List > MLS1547

MLS1547

Product Name: MLS1547
CAS No.: 315698-36-3
Chemical Name: MLS1547
Synonyms: MLS1547;MLS000051547;MLS1547[SML1331];MLS1547 >=98% (HPLC);MLS1547, 10 mM in DMSO;5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol;8-Quinolinol, 5-chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-;Inhibitor,inhibit,biased,β-arrestin,MLS1547,Dopamine Receptor,protein,signaling,recruitment
CBNumber: CB53067562
Molecular Formula: C19H19ClN4O
Formula Weight: 354.83
MOL File: 315698-36-3.mol

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MLS1547 Property

Boiling point:: 555.8±50.0 °C(Predicted)
Density: 1.354±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
form: A crystalline solid
pka: 4.08±0.30(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1331
Product name: MLS1547
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $100
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1331
Product name: MLS1547
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $393
Updated: 2025/07/31

Cayman Chemical

Product number: 27648
Product name: MLS-1547
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 27648
Product name: MLS-1547
Packaging: 25mg
Price: $343
Updated: 2024/03/01

Cayman Chemical

Product number: 27648
Product name: MLS-1547
Packaging: 1mg
Price: $32
Updated: 2024/03/01

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MLS1547 Chemical Properties,Usage,Production

Uses

MLS 1547 is a dopamine D2 receptor partial agonist which may be used in the preparation of or combination with antipsychotic drugs.

Biological Activity

MLS1547 is a highly efficacious D2 dopamine receptor (D2R) G protein-biased agonist th at does not recruit β-arrestin, and is an antagonist of dopamine-stimulated β-arrestin recruitment to the D2 receptor. MLS-1547 is the first D2 receptor agonist with close to full efficacy for G protein signaling (EC50 = 370 nM), but no ability to recruit β-arrestin.

IC 50

D₂ Receptor

storage

Store at +4°C

MLS1547 Preparation Products And Raw materials

Raw materials

Preparation Products

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315698-36-3, MLS1547Related Search:

MLS1547

5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol

8-Quinolinol, 5-chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-

MLS1547 >=98% (HPLC)

MLS000051547

Inhibitor,inhibit,biased,β-arrestin,MLS1547,Dopamine Receptor,protein,signaling,recruitment

MLS1547, 10 mM in DMSO

MLS1547[SML1331]

315698-36-3