TASP0415914

Product Name: TASP0415914
CAS No.: 1292300-75-4
Chemical Name: TASP0415914
Synonyms: CS-2671;TSAP0415914;TASP0415914;N-(5-(3-(3-Hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl)-4-methylthiazol-2-yl)acetamide;Acetamide, N-[5-[3-(3-hydroxy-1-piperidinyl)-1,2,4-oxadiazol-5-yl]-4-methyl-2-thiazolyl]-;TASP 0415914,inhibit,inflammatory,PKB,stability,TASP0415914,PI3Kγ,oral,Akt,Phosphoinositide 3-kinase,Protein kinase B,TASP-0415914,Inhibitor,autoimmune,PI3K,metabolic
CBNumber: CB53067582
Molecular Formula: C13H17N5O3S
Formula Weight: 323.37
MOL File: 1292300-75-4.mol

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TASP0415914 Property

Density: 1.435±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (386.55 mM; Need ultrasonic)
pka: 9.14±0.50(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 215892
Product name: TASP-0415914
Packaging: 1mg
Price: $420
Updated: 2021/12/16

AK Scientific

Product number: SYN1208
Product name: TASP0415914
Packaging: 100mg
Price: $2270
Updated: 2021/12/16

Adipogen Life Sciences

Product number: SYN-1208-M100
Product name: TASP0415914
Purity: ≥95%
Packaging: 100mg
Price: $2430
Updated: 2021/12/16

Adipogen Life Sciences

Product number: SYN-1208-M005
Product name: TASP0415914
Purity: ≥95%
Packaging: 5mg
Price: $313
Updated: 2021/12/16

DC Chemicals

Product number: DC8531
Product name: TASP0415914
Purity: >98%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

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TASP0415914 Chemical Properties,Usage,Production

Biological Activity

TASP0415914 is a potent and orally active PI3Kγ inhibitor with an IC50 of 29 nM. TASP0415914 also shows potent Akt inhibitory activities with an IC50 of 294 nM. TASP0415914 can be used for inflammatory diseases research[1]. TASP0415914 (compound 8j) shows high metabolic stability in rat/human liver microsomes. TASP0415914 has no CYP inhibition up to 10 μM for CYP1A2, 2C9, 2C19, 2D6 and 3A4[1]. TASP0415914 (compound 8j; 10-100 mg/kg; orally administration; twice daily; for 14 days) treatment suppressed the progression of the disease in a dose-dependent manner in a mouse collagen-induced arthritis (CIA) model[1].

References

[1]. Yusuke Oka, et al. Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases. Bioorg Med Chem. 2013 Dec 15;21(24):7578-83.

TASP0415914 Preparation Products And Raw materials

Raw materials

Preparation Products

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1292300-75-4, TASP0415914Related Search:

TASP0415914

TSAP0415914

CS-2671

TASP 0415914,inhibit,inflammatory,PKB,stability,TASP0415914,PI3Kγ,oral,Akt,Phosphoinositide 3-kinase,Protein kinase B,TASP-0415914,Inhibitor,autoimmune,PI3K,metabolic

Acetamide, N-[5-[3-(3-hydroxy-1-piperidinyl)-1,2,4-oxadiazol-5-yl]-4-methyl-2-thiazolyl]-

N-(5-(3-(3-Hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl)-4-methylthiazol-2-yl)acetamide

1292300-75-4