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TASP0415914

Product Name
TASP0415914
CAS No.
1292300-75-4
Chemical Name
TASP0415914
Synonyms
CS-2671;TSAP0415914;TASP0415914;TASP0415914, 10 mM in DMSO;N-(5-(3-(3-Hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl)-4-methylthiazol-2-yl)acetamide;Acetamide, N-[5-[3-(3-hydroxy-1-piperidinyl)-1,2,4-oxadiazol-5-yl]-4-methyl-2-thiazolyl]-;N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide;TASP 0415914,inhibit,inflammatory,PKB,stability,TASP0415914,PI3Kγ,oral,Akt,Phosphoinositide 3-kinase,Protein kinase B,TASP-0415914,Inhibitor,autoimmune,PI3K,metabolic
CBNumber
CB53067582
Molecular Formula
C13H17N5O3S
Formula Weight
323.37
MOL File
1292300-75-4.mol
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TASP0415914 Property

Density 
1.435±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 125 mg/mL (386.55 mM; Need ultrasonic)
pka
9.14±0.50(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
215892
Product name
TASP-0415914
Packaging
1mg
Price
$420
Updated
2021/12/16
AK Scientific
Product number
SYN1208
Product name
TASP0415914
Packaging
100mg
Price
$2270
Updated
2021/12/16
Adipogen Life Sciences
Product number
SYN-1208-M100
Product name
TASP0415914
Purity
≥95%
Packaging
100mg
Price
$2430
Updated
2021/12/16
Adipogen Life Sciences
Product number
SYN-1208-M005
Product name
TASP0415914
Purity
≥95%
Packaging
5mg
Price
$313
Updated
2021/12/16
DC Chemicals
Product number
DC8531
Product name
TASP0415914
Purity
>98%
Packaging
50mg
Price
$450
Updated
2021/12/16
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TASP0415914 Chemical Properties,Usage,Production

Uses

TASP0415914 is a potent and orally active PI3Kγ inhibitor with an IC50 of 29 nM. TASP0415914 also shows potent Akt inhibitory activities with an IC50 of 294 nM. TASP0415914 can be used for inflammatory diseases research[1].

Biological Activity

TASP0415914 is a potent and orally active PI3Kγ inhibitor with an IC50 of 29 nM. TASP0415914 also shows potent Akt inhibitory activities with an IC50 of 294 nM. TASP0415914 can be used for inflammatory diseases research[1]. TASP0415914 (compound 8j) shows high metabolic stability in rat/human liver microsomes. TASP0415914 has no CYP inhibition up to 10 μM for CYP1A2, 2C9, 2C19, 2D6 and 3A4[1]. TASP0415914 (compound 8j; 10-100 mg/kg; orally administration; twice daily; for 14 days) treatment suppressed the progression of the disease in a dose-dependent manner in a mouse collagen-induced arthritis (CIA) model[1].

in vivo

TASP0415914 (compound 8j; 10-100 mg/kg; orally administration; twice daily; for 14 days) treatment suppressed the progression of the disease in a dose-dependent manner in a mouse collagen-induced arthritis (CIA) model[1].

Animal Model:Collagen-primed DBA/1 mice[1]
Dosage:10 mg/kg; 30 mg/kg; 100 mg/kg
Administration:Orally administration; twice daily; for 14 days
Result:Suppressed the progression of the disease in a dose-dependent manner.

IC 50

PI3Kγ: 29 nM (IC50)

References

[1]. Yusuke Oka, et al. Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases. Bioorg Med Chem. 2013 Dec 15;21(24):7578-83.

TASP0415914 Preparation Products And Raw materials

Raw materials

Preparation Products

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TASP0415914 Suppliers

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1292300-75-4, TASP0415914Related Search:


  • TASP0415914
  • TSAP0415914
  • CS-2671
  • TASP 0415914,inhibit,inflammatory,PKB,stability,TASP0415914,PI3Kγ,oral,Akt,Phosphoinositide 3-kinase,Protein kinase B,TASP-0415914,Inhibitor,autoimmune,PI3K,metabolic
  • Acetamide, N-[5-[3-(3-hydroxy-1-piperidinyl)-1,2,4-oxadiazol-5-yl]-4-methyl-2-thiazolyl]-
  • N-(5-(3-(3-Hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl)-4-methylthiazol-2-yl)acetamide
  • N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide
  • TASP0415914, 10 mM in DMSO
  • 1292300-75-4