6-chloro-5-iodopyrimidin-4-amine
- Product Name
- 6-chloro-5-iodopyrimidin-4-amine
- CAS No.
- 353272-15-8
- Chemical Name
- 6-chloro-5-iodopyrimidin-4-amine
- Synonyms
- 6-chloro-5-iodopyrimidin-4-amine;4-Amino-6-chloro-5-iodopyrimidine;4-Pyrimidinamine, 6-chloro-5-iodo-;6-Chloro-5-iodopyrimidin-4-ylamine
- CBNumber
- CB53096201
- Molecular Formula
- C4H3ClIN3
- Formula Weight
- 255.44
- MOL File
- 353272-15-8.mol
6-chloro-5-iodopyrimidin-4-amine Property
- Boiling point:
- 362.7±42.0 °C(Predicted)
- Density
- 2.276±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 0.51±0.10(Predicted)
- Appearance
- Yellow to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8470DG
- Product name
- 6-Chloro-5-iodopyrimidin-4-amine
- Packaging
- 10g
- Price
- $976
- Updated
- 2021/12/16
- Product number
- CM252437
- Product name
- 6-Chloro-5-iodopyrimidin-4-amine
- Purity
- 95%
- Packaging
- 1g
- Price
- $122
- Updated
- 2021/12/16
- Product number
- SC-36194
- Product name
- 6-Chloro-5-iodopyrimidin-4-ylamine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- CM252437
- Product name
- 6-Chloro-5-iodopyrimidin-4-amine
- Purity
- 95%
- Packaging
- 5g
- Price
- $374
- Updated
- 2021/12/16
- Product number
- CD11137425
- Product name
- 6-Chloro-5-iodopyrimidin-4-amine
- Purity
- 97%
- Packaging
- 5g
- Price
- $396
- Updated
- 2021/12/16
6-chloro-5-iodopyrimidin-4-amine Chemical Properties,Usage,Production
Synthesis
5305-59-9
353272-15-8
General procedure for the synthesis of 6-chloro-5-iodopyrimidin-4-amine from 4-amino-6-chloropyrimidine: 3.03 g (23.39 mmol) of 6-chloropyrimidin-4-amine was dissolved in 60 mL of anhydrous dimethylformamide (DMF) under nitrogen protection and stirred until complete dissolution. Subsequently, 2.34 mL (46.70 mmol) of iodine monochloride (ICl) was dissolved in 40 mL of anhydrous DMF and slowly added dropwise to the above solution, with the rate of dropwise acceleration being controlled to maintain a stable reaction temperature. After dropwise addition, the reaction mixture was heated to 45 °C and the reaction was stirred at this temperature overnight (about 12 hours). Upon completion of the reaction, most of the DMF was removed by rotary evaporator under reduced pressure. the residue was transferred to a partition funnel and extracted by partition with dichloromethane (DCM) and 4% aqueous sodium bicarbonate. The organic layer was separated and washed sequentially with deionized water and saturated saline to remove water-soluble impurities and residual DMF.The organic layer was dried over anhydrous magnesium sulfate, filtered to remove the desiccant, and the filtrate was again concentrated to dryness by rotary evaporator. The crude product was purified by fast column chromatography using a solvent mixture of dichloromethane and methanol as eluent (methanol percentage was increased from 0% to 20% in a gradient) and fractions containing the target product were collected. Finally, the solvent was evaporated under reduced pressure to give 4.28 g of 6-chloro-5-iodopyrimidin-4-amine as a white solid in 72% yield. The product was confirmed by low resolution mass spectrometry (LRMS), m/z: 256 ([M+H]+).
References
[1] Patent: WO2014/60432, 2014, A1. Location in patent: Page/Page column 128; 129
[2] Journal of Heterocyclic Chemistry, 2014, vol. 51, # SUPPL. 1, p. E380-E383
[3] Tetrahedron Letters, 2010, vol. 51, # 27, p. 3597 - 3598
[4] Patent: WO2015/175579, 2015, A1. Location in patent: Paragraph 346
[5] Patent: CN104513235, 2017, B. Location in patent: Paragraph 0765; 0766; 0767
6-chloro-5-iodopyrimidin-4-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-chloro-5-iodopyrimidin-4-amine manufacturers
- Product
- 6-chloro-5-iodopyrimidin-4-amine 353272-15-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-25