5-(T-BOC-AMINO)-1-PENTYL BROMIDE
- Product Name
- 5-(T-BOC-AMINO)-1-PENTYL BROMIDE
- CAS No.
- 83948-54-3
- Chemical Name
- 5-(T-BOC-AMINO)-1-PENTYL BROMIDE
- Synonyms
- tert-Butyl (5-broMopentyl)carbaMate;5-(Boc-aMino)pentyl broMide;N-Boc-5-bromo-1-pentanamine;5-(Boc-amino)-1-pentyl bromide;5-(T-BOC-AMINO)-1-PENTYL BROMIDE;ert-butyl (5-bromopentyl)carbamate;tert-butyl N-(5-bromopentyl)carbamate;5-(tert-Butoxycarbonylamino)pentyl bromide;1,1-DiMethylethyl (5-broMopentyl)carbaMate;N-(tert-Butoxycarbonyl)-1-bromopentan-5-ylamine
- CBNumber
- CB5309621
- Molecular Formula
- C10H20BrNO2
- Formula Weight
- 266.18
- MOL File
- Mol file
5-(T-BOC-AMINO)-1-PENTYL BROMIDE Property
- Melting point:
- approx. 35°C
- Boiling point:
- 324℃
- Density
- 1.214
- Flash point:
- 150℃
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Chloroform, Ethyl Acetate, Methanol
- form
- Solid
- pka
- 12.87±0.46(Predicted)
- color
- White Low melting
- InChI
- InChI=1S/C10H20BrNO2/c1-10(2,3)14-9(13)12-8-6-4-5-7-11/h4-8H2,1-3H3,(H,12,13)
- InChIKey
- OHUJQWJCNMMZFM-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)NCCCCCBr
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- D6423
- Product name
- tert-Butyl (5-Bromopentyl)carbamate
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $117
- Updated
- 2025/07/31
- Product number
- B621075
- Product name
- 5-(t-Boc-amino)-1-pentylBromide
- Packaging
- 1g
- Price
- $505
- Updated
- 2021/12/16
- Product number
- B621075
- Product name
- 5-(t-Boc-amino)-1-pentylBromide
- Packaging
- 5g
- Price
- $1980
- Updated
- 2021/12/16
- Product number
- CS-0006785
- Product name
- tert-butyl(5-bromopentyl)carbamate
- Packaging
- 250mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- FB18909
- Product name
- 5-(t-Boc-amino)-1-pentyl bromide
- Packaging
- 1g
- Price
- $850
- Updated
- 2021/12/16
5-(T-BOC-AMINO)-1-PENTYL BROMIDE Chemical Properties,Usage,Production
Chemical Properties
Low melting solid
Synthesis
75178-90-4
83948-54-3
The general procedure for the synthesis of 5-Boc-amino-1-pentyl bromide from 5-(N-tert-butoxycarbonylamino)-1-pentanol was as follows: 5-(N-tert-butoxycarbonylamino)-1-pentanol (3.00 g, 14.8 mmol) was dissolved in THF (41 mL) and cooled to 0 °C. CBr4 (7.34 g, 22.1 mmol) and PPh3 (5.96 g, 22.7 mmol) were added sequentially. After stirring at 0 °C for 1 h, CBr4 (2.55 g, 7.68 mmol) and PPh3 (2.17 g, 8.27 mmol) were added. The reaction mixture was continued to be stirred at room temperature for 14 hours. After completion of the reaction, it was diluted with 30% EtOAc/hexane, filtered and washed with the same ratio of EtOAc/hexane. The filtrates were combined, concentrated in vacuum and the residue was purified by silica gel column chromatography (eluent: CHCl3/hexane, gradient from 20% to 100%) to afford the target product tert-butyl N-(5-bromopentyl)carbamate (3.2 g, 81% yield).
References
[1] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 5, p. 510 - 515
[2] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 11, p. 1156 - 1161
[3] Journal of Medicinal Chemistry, 2018, vol. 61, # 17, p. 7892 - 7901
[4] Patent: WO2012/177782, 2012, A1. Location in patent: Page/Page column 87
[5] Journal of Organic Chemistry, 1983, vol. 48, p. 24
5-(T-BOC-AMINO)-1-PENTYL BROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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