ChemicalBook > CAS DataBase List > Levosimendan

Levosimendan

Product Name
Levosimendan
CAS No.
141505-33-1
Chemical Name
Levosimendan
Synonyms
Simda;Simdax;OR-1259;LEVOSIMENDAN;(R)-Simendan;LevosimendanC14H12N60;Levosimendan USP/EP/BP;Levosimendan Basic information;(R)-2-[[4-(1,4,5,6-TETRAHYDRO-4-METHYL-6-OXO-3-PYRIDAZINYL)PHENYL] HYDROZONO]PRO;-2-[[4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)19henyl]hydrazono]Propandinitrile
CBNumber
CB5310540
Molecular Formula
C14H12N6O
Formula Weight
280.28
MOL File
141505-33-1.mol
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Levosimendan Property

Melting point:
216-219°C (dec.)
alpha 
D25 -566° (tetrahydrofurane/methanol)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: ≥20mg/mL
pka
6.3(at 25℃)
form 
powder
color 
yellow
optical activity
[α]/D -500 to -650°, c = 0.5 in THF
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36/37
WGK Germany 
3
RTECS 
TY1570210
Toxicity
LD50 in male, female mice, male rats (mg/kg): 156, 152, 103 orally; 32, 50, 57 i.v. (Pagel)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L5545
Product name
Levosimendan
Purity
≥98% (HPLC)
Packaging
10mg
Price
$70.4
Updated
2021/03/22
Sigma-Aldrich
Product number
L5545
Product name
Levosimendan
Purity
≥98% (HPLC)
Packaging
50mg
Price
$285
Updated
2021/03/22
TCI Chemical
Product number
L0320
Product name
Levosimendan
Purity
>98.0%(HPLC)
Packaging
250mg
Price
$364
Updated
2021/03/22
TCI Chemical
Product number
L0320
Product name
Levosimendan
Purity
>98.0%(HPLC)
Packaging
50mg
Price
$122
Updated
2021/03/22
Cayman Chemical
Product number
16128
Product name
Levosimendan
Purity
≥98%
Packaging
50mg
Price
$45
Updated
2021/03/22
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Levosimendan Chemical Properties,Usage,Production

Description

Levosimendan was introduced in Sweden as an i.v. infusion for the treatment of acute heart failure or refractory symptoms of chronic heart failure in cases where conventional treatment (e.g., diuretic or ACE inhibitor) is not sufficient. Levosimendan is the (R)- enantiomer of simendan that belongs to the same class as pimobendan (Boehringer Ingelheim). Levosimendan is an innovative myofilament calcium sensitizer that increases myocardial contractility by selectively binding to the N-terminus of troponin C and by stabilizing the Ca2+-bound conformation of this contractile protein. It also activates ventricular and arterial adenostne triphosphate-regulated potassium channels which causes vasodilatation in vascular smooth muscle and protects myocardium against infarction. Its low phosphodiesterase III inhibiting activity is probably not responsible for its positive inotropic, lusitropic and dilating effects. Unlike other cardiotonic drugs, levosimendan is able to produce positive inotropic effects without prolonging myocardial relaxation or increasing the incidence of malignant arrythmias. It was clinically shown to have a lower risk of mortality in patients with heart failure when compared to placebo and dobutamine. Since it has a larger potential, levosimendan is currently under further clinical evaluation as a chronic treatment for congestive heart failure.

Chemical Properties

Yellow Crystalline Powder

Originator

Orion (Finland)

Uses

Bioactive enantiomer of racemate, Simendan. Positive inotropic agent with vasodilating activity. Cardiotonic

Uses

anesthetic

brand name

Simdax (Orion Pharmaceutica, Finland).

Levosimendan Preparation Products And Raw materials

Raw materials

Preparation Products

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Levosimendan Suppliers

SiChuang NanBu Honesty Technology Co., Ltd.
Tel
0838-5675166
Fax
0838-5675535
Email
nbcxkj@126.com
Country
China
ProdList
669
Advantage
55
Tianyuan Natural Product Co.,Ltd.
Tel
028-85012281
Fax
86-28-85121102
Email
xianlihong8888@163.com
Country
China
ProdList
49
Advantage
62
Wuhan Yanzhe Technology Co., Ltd
Tel
Fax
QQ:2692360204
Email
wenhaotian12@163.com
Country
China
ProdList
4556
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Sichuan Ruibo Technology Co., Ltd
Tel
+86-817-5586080
Fax
+86-817-5527378
Email
sales@scrbkj.com
Country
China
ProdList
42
Advantage
69
Chembest Research Laboratories Limited
Tel
021-20908456-
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5948
Advantage
61
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43495
Advantage
61
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078;021-50426030
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
10006
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100-
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9639
Advantage
66
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
9917
Advantage
62
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View Lastest Price from Levosimendan manufacturers

Hebei Guanlang Biotechnology Co., Ltd.
Product
Levosimendan 141505-33-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-09-10
Dideu Industries Group Limited
Product
Levosimendan USP/EP/BP 141505-33-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-06
Zhuozhou Wenxi import and Export Co., Ltd
Product
levosimendan 141505-33-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

141505-33-1, LevosimendanRelated Search:


  • LEVOSIMENDAN
  • -2-[[4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)19henyl]hydrazono]Propandinitrile
  • (R)-Simendan
  • [[4-[(4R)-1,4,5,6-Terahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazono]propanedinitrile
  • OR-1259
  • Simda
  • Mesoxalonitrile (-)-{p-[(R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl}hydrazone
  • (R)-2-[[4-(1,4,5,6-TETRAHYDRO-4-METHYL-6-OXO-3-PYRIDAZINYL)PHENYL] HYDROZONO]PRO
  • LevosimendanC14H12N60
  • Simdax
  • 2-[[4-[(4R)-4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl]phenyl]hydrazinylidene]propanedinitrile
  • Propanedinitrile, [[4-[(4R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazono]-
  • Propanedinitrile,2-[2-[4-[(4R)-1,4,5,6-tetrahydro-4-Methyl-6-oxo-3-pyridazinyl]phenyl]hydrazinylidene]-
  • (R)-2-(2-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)hydrazono)malononitrile
  • 2-[2-[4-[(4R)-1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazinylidene]-propanedinitrile
  • R)-((4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazono) propanedintrile
  • Levosimendan Basic information
  • (R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)carbonohydrazonoyl dicyanide
  • Levosimendan USP/EP/BP
  • 141505-33-1
  • 6300-7-8
  • C14H12N6O
  • Inhibitors
  • FLUOTHANE
  • Intermediates & Fine Chemicals
  • Pharmaceuticals