2,3,5,6-TETRACHLOROPHENOL Property

Melting point:

115-116℃ (isooctane )

Boiling point:

331.59°C (rough estimate)

Density 

1.6 g/cm3 (60℃)

refractive index 

1.5133 (estimate)

Flash point:

11 °C

storage temp. 

APPROX 4°C

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

pka

5.09±0.20(Predicted)

Water Solubility 

0.1g/L(25 ºC)

BRN 

2049586

CAS DataBase Reference

935-95-5(CAS DataBase Reference)

EPA Substance Registry System

2,3,5,6-Tetrachlorophenol (935-95-5)

Safety

Hazard Codes 

T,F

Risk Statements 

25-37/38-41-39/23/24/25-23/24/25-11

Safety Statements 

26-39-45-36/37-16

RIDADR 

UN 2020 6.1/PG 3

WGK Germany 

3

RTECS 

SM9450000

Hazardous Substances Data

935-95-5(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H335May cause respiratory irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

2,3,5,6-TETRACHLOROPHENOL Chemical Properties,Usage,Production

Chemical Properties

Brown solid; phenol odor. Soluble in sodium hydroxide solutions and most organic solvents; insoluble in water.

Uses

Fungicide, wood preservative.

Production Methods

Chlorophenols are generally prepared by the chlorination of phenol. There are other routes of synthesis as through diazotizing p-chloroaniline or dechlorinating (by alkaline hydrolysis) 1,2,4,5-tetrachlorobenzene to yield 2,4,5-trichlorophenol (TCP). Polychlorinated dibenzo-p-dioxins can be formedduringthemanufacturingprocess of the chlorophenols. The amount formed depends on temperature and pressure process variability during production. The more notable toxic dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD), is formed during the production of 2,4,5- TCP. Laboratory reference standards of 2,3,7,8-TCDD are prepared by heating 2,4,5-TCP under alkaline conditions. All technical and formulated products containing 2,4,5-TCP are expected to be contaminated to varying degrees by this 2,3,7,8-TCDD by-product of the manufacturing process.

Definition

ChEBI: The 2,3,5,6-isomer of tetrachlorophenol

General Description

Leaflets (from ligroin) or light beige powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2,3,5,6-TETRACHLOROPHENOL is incompatible with acid chlorides, acid anhydrides and oxidizing agents. .

Hazard

Toxic by ingestion and inhalation, strong irritant.

Fire Hazard

Flash point data for 2,3,5,6-TETRACHLOROPHENOL are not available. 2,3,5,6-TETRACHLOROPHENOL is probably combustible.

Carcinogenicity

There was no evidence of carcinogenic activity of 2,4-dichlorophenol in F344/N rats or B6C3F1 mice from the NTP bioassay program, but 2,4,6-trichlorophenol was reported to be carcinogenic in both species.

Purification Methods

Crystallise the phenol from pet ethers. The benzoate has m 136o (from EtOH). [Beilstein 6 II 182, 6 III 730, 6 IV 1025.]