ChemicalBook > CAS DataBase List > GPRP (acetate)

GPRP (acetate)

Product Name: GPRP (acetate)
CAS No.: 157009-81-9
Chemical Name: GPRP (acetate)
Synonyms: Pefa 6003;Pefabloc FG);GPRP (acetate);GPRP ACETATE, >98%;H-Gly-Pro-Arg-Pro-OH (acetate);GPRP acetate (67869-62-9 free base);GLY-PRO-ARG-PRO ACETATE;PEFABLOC FG;GPRP acetate (Gly-Pro-Arg-Pro acetate;L-Proline, glycyl-L-prolyl-L-arginyl-, acetate (1:1);GPRP acetate,Gly-Pro-Arg-Pro acetate,Glycyl-L-prolyl-L-arginyl-L-proline acetate,Pefa 6003,Pefabloc FG, >98%
CBNumber: CB53121103
Molecular Formula: C20H35N7O7
Formula Weight: 485.54
MOL File: 157009-81-9.mol

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GPRP (acetate) Property

solubility: PBS (pH 7.2): 10 mg/ml
form: A crystalline solid
color: White to off-white
Sequence: H-Gly-Pro-Arg-Pro-OH

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21163
Product name: H-Gly-Pro-Arg-Pro-OH (acetate)
Purity: ≥95%
Packaging: 1mg
Price: $28
Updated: 2024/03/01

Cayman Chemical

Product number: 21163
Product name: H-Gly-Pro-Arg-Pro-OH (acetate)
Purity: ≥95%
Packaging: 5mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 21163
Product name: H-Gly-Pro-Arg-Pro-OH (acetate)
Purity: ≥95%
Packaging: 10mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 21163
Product name: H-Gly-Pro-Arg-Pro-OH (acetate)
Purity: ≥95%
Packaging: 25mg
Price: $161
Updated: 2024/03/01

AK Scientific

Product number: 6190EF
Product name: GPRPacetate
Packaging: 1mg
Price: $128
Updated: 2021/12/16

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GPRP (acetate) Chemical Properties,Usage,Production

Uses

GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa)[1][2][3].

in vivo

GPRP acetate (100 mg/kg; i.p., once daily for 10 days) significantly alleviates DSS-induced colitis through the improvement of body weight loss and mortality^[3].

Animal Model:	C57BL/6 mice with dextran sulphate sodium (DSS)-induced colitis^[3]
Dosage:	100 mg/kg
Administration:	Intraperitoneal injection; 100 mg/kg, once daily, for 10 days
Result:	Significantly inhibited body weight loss and reduced DSS-induced mortality and shortening of colon length, and decreased tissue damage and infiltration of inflammatory cells in colitis mice. Decreased levels of inflammatory cytokines in colitis mice.

References

[1] Gallistl S, et al. Gly-pro-arg-pro (GPRP) enhances free thrombin. Thromb Res. 1995 Jun 15;78(6):547-50. DOI:10.1016/0049-3848(95)e0088-8
[2] Hsieh KH, et, al. Fibrin Polymerization. 1. Alkylating peptide inhibitors of fibrin polymerization. J Med Chem. 1981 Mar; 24(3): 322-7. DOI:10.1021/jm00135a016
[3] Zhang C, et al. Fibrinogen/AKT/Microfilament Axis Promotes Colitis by Enhancing Vascular Permeability. Cell Mol Gastroenterol Hepatol. 2021;11(3):683-696. DOI:10.1016/j.jcmgh.2020.10.007

GPRP (acetate) Preparation Products And Raw materials

Raw materials

Preparation Products

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157009-81-9, GPRP (acetate)Related Search:

FIBRINOGEN GAMMA-CHAIN (117-133) FIBRINOGEN GAMMA-CHAIN (397-411) FIBRONECTIN CS-1 FRAGMENT (1978-1985) HIS-HIS-LEU-GLY-GLY-ALA-LYS-GLN-ALA-GLY-ASP-VAL FIBRINOPEPTIDE B

GPRP acetate (Gly-Pro-Arg-Pro acetate

Pefabloc FG)

GPRP ACETATE, >98%

GPRP acetate,Gly-Pro-Arg-Pro acetate,Glycyl-L-prolyl-L-arginyl-L-proline acetate,Pefa 6003,Pefabloc FG, >98%

GLY-PRO-ARG-PRO ACETATE;PEFABLOC FG

GPRP (acetate)

H-Gly-Pro-Arg-Pro-OH (acetate)

Pefa 6003

GPRP acetate (67869-62-9 free base)

L-Proline, glycyl-L-prolyl-L-arginyl-, acetate (1:1)

fibrinogen,GPRP acetate (67869 62 9 free base),Fibrin,inhibit,polymerization,GPRP,Pefa6003,IIb/IIIa,Pefa-6003,GPIIb/IIIa,glycoprotein,Inhibitor,platelet,GPRP acetate (67869629 free base)

(S)-1-((S)-2-((S)-1-(2-aminoacetyl)pyrrolidine-2-carboxamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxylic acid compound with acetic acid (1:1)

(S)-1-((S)-2-((S)-1-(2-Aminoacetyl)pyrrolidine-2-carboxamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxylic acid acetate

157009-81-9