DG172 (dihydrochloride)

Product Name: DG172 (dihydrochloride)
CAS No.: 1361504-77-9
Chemical Name: DG172 (dihydrochloride)
Synonyms: DG-172;DG172 2HCl;DG-172 (hydrochloride);DG172 (dihydrochloride);(Z)-2-(2-Bromophenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)acrylonitrile dihydrochloride;(αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitriledihydrochloride;(αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride;DG-172,DG172,DG172 dihydrochloride,PPAR,inhibit,DG 172,Inhibitor,Peroxisome proliferator-activated receptors
CBNumber: CB53122342
Molecular Formula: C20H21BrClN3
Formula Weight: 418.76
MOL File: 1361504-77-9.mol

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DG172 (dihydrochloride) Property

storage temp.: Store at -20°C
solubility: ≤20mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide
form: crystalline solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19128
Product name: DG-172 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $29
Updated: 2024/03/01

Cayman Chemical

Product number: 19128
Product name: DG-172 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $99
Updated: 2024/03/01

Cayman Chemical

Product number: 19128
Product name: DG-172 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

Cayman Chemical

Product number: 19128
Product name: DG-172 (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $352
Updated: 2024/03/01

Tocris

Product number: 5566
Product name: DG172dihydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $183
Updated: 2021/12/16

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DG172 (dihydrochloride) Chemical Properties,Usage,Production

Description

DG-172 is an orally available inverse agonist of PPARβ/δ (IC₅₀ = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC₅₀ = 9.5 nM). It alters the differentiation of bone marrow cells, augmenting GM-CSF-induced development into subsets of mature and immature dendritic cells. Inverse agonists of PPARβ/δ, including DG-172, inhibit cancer cell invasion through suppression of ANGPTL4 expression.

Uses

DG 172 Dihydrochloride is a potent peroxisome proliferator-activated receptor agonist and inhibit Angptl4 gene expression in mouse myoblasts.

References

[1]. lieber s, scheer f, meissner w, et al. (z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (dg172): an orally bioavailable pparβ/δ-selective ligand with inverse agonistic properties. j med chem. 2012 mar 22;55(6):2858-68.
[2]. lieber s, scheer f, finkernagel f, et al. the inverse agonist dg172 triggers a pparβ/δ-independent myeloid lineage shift and promotes gm-csf/il-4-induced dendritic cell differentiation. mol pharmacol. 2015 feb;87(2):162-73.
[3]. adhikary t, brandt dt, kaddatz k, et al. inverse pparβ/δ agonists suppress oncogenic signaling to the angptl4 gene and inhibit cancer cell invasion. oncogene. 2013 oct 31;32(44):5241-52.

DG172 (dihydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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DG172 (dihydrochloride) Suppliers

China 37 United Kingdom 1 United States 10 Global 48

Haoyuan Chemexpress Co., Ltd.

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Shanghai SuperLan Chemcial Technique Centre

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Musechem

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Angel Pharmatech, Ltd.

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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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