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DG172 (dihydrochloride)

Product Name
DG172 (dihydrochloride)
CAS No.
1361504-77-9
Chemical Name
DG172 (dihydrochloride)
Synonyms
DG-172;DG172 2HCl;DG-172 (hydrochloride);DG172 (dihydrochloride);(Z)-2-(2-Bromophenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)acrylonitrile dihydrochloride;(αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitriledihydrochloride;(αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride;DG-172,DG172,DG172 dihydrochloride,PPAR,inhibit,DG 172,Inhibitor,Peroxisome proliferator-activated receptors
CBNumber
CB53122342
Molecular Formula
C20H21BrClN3
Formula Weight
418.76
MOL File
1361504-77-9.mol
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DG172 (dihydrochloride) Property

storage temp. 
Store at -20°C
solubility 
≤20mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide
form 
crystalline solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19128
Product name
DG-172 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$29
Updated
2024/03/01
Cayman Chemical
Product number
19128
Product name
DG-172 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$99
Updated
2024/03/01
Cayman Chemical
Product number
19128
Product name
DG-172 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$169
Updated
2024/03/01
Cayman Chemical
Product number
19128
Product name
DG-172 (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$352
Updated
2024/03/01
Tocris
Product number
5566
Product name
DG172dihydrochloride
Purity
≥98%(HPLC)
Packaging
10
Price
$183
Updated
2021/12/16
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DG172 (dihydrochloride) Chemical Properties,Usage,Production

Description

DG-172 is an orally available inverse agonist of PPARβ/δ (IC50 = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC50 = 9.5 nM). It alters the differentiation of bone marrow cells, augmenting GM-CSF-induced development into subsets of mature and immature dendritic cells. Inverse agonists of PPARβ/δ, including DG-172, inhibit cancer cell invasion through suppression of ANGPTL4 expression.

Uses

DG 172 Dihydrochloride is a potent peroxisome proliferator-activated receptor agonist and inhibit Angptl4 gene expression in mouse myoblasts.

References

[1]. lieber s, scheer f, meissner w, et al. (z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (dg172): an orally bioavailable pparβ/δ-selective ligand with inverse agonistic properties. j med chem. 2012 mar 22;55(6):2858-68.
[2]. lieber s, scheer f, finkernagel f, et al. the inverse agonist dg172 triggers a pparβ/δ-independent myeloid lineage shift and promotes gm-csf/il-4-induced dendritic cell differentiation. mol pharmacol. 2015 feb;87(2):162-73.
[3]. adhikary t, brandt dt, kaddatz k, et al. inverse pparβ/δ agonists suppress oncogenic signaling to the angptl4 gene and inhibit cancer cell invasion. oncogene. 2013 oct 31;32(44):5241-52.

DG172 (dihydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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DG172 (dihydrochloride) Suppliers

MedChemexpress LLC
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marketing@targetmol.com
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1361504-77-9, DG172 (dihydrochloride)Related Search:


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  • (Z)-2-(2-Bromophenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)acrylonitrile dihydrochloride
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