Lu AF21934
- Product Name
- Lu AF21934
- CAS No.
- 1445605-23-1
- Chemical Name
- Lu AF21934
- Synonyms
- CS-2215;Lu AF21934;LuAF21934, >98%;LU-AF 21934;LU AF 21934;LU AF-21934;LU AF 21934;LU-AF21934;LU-AF-21934;(1S,2R)-N1-(3,4-Dichlorophenyl)-1,2-cyclohexanedicarboxamide;(1S,2R)-N1-(3,4-Dichlorophenyl)cyclohexane-1,2-dicarboxamide;1,2-Cyclohexanedicarboxamide, N1-(3,4-dichlorophenyl)-, (1S,2R)-;2-PYRIMIDINAMINE,4-METHYL-N-[5-METHYL-4-(1H-PYRAZOL-4-YL)-2-THIAZOLYL]-, >98%;Lu AF-21934,Inhibitor,Lu AF 21934,Metabotropic glutamate receptors,inhibit,mGluR,Lu AF21934
- CBNumber
- CB53129361
- Molecular Formula
- C14H16Cl2N2O2
- Formula Weight
- 315.2
- MOL File
- 1445605-23-1.mol
Lu AF21934 Property
- Boiling point:
- 577.6±50.0 °C(Predicted)
- Density
- 1.386±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥31.5 mg/mL in DMSO; insoluble in H2O; ≥5.03 mg/mL in EtOH with ultrasonic
- form
- solid
- pka
- 13.23±0.70(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 27045
- Product name
- Lu AF21934
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- 27045
- Product name
- Lu AF21934
- Packaging
- 25mg
- Price
- $479
- Updated
- 2024/03/01
- Product number
- 27045
- Product name
- Lu AF21934
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 27045
- Product name
- Lu AF21934
- Packaging
- 10mg
- Price
- $214
- Updated
- 2024/03/01
- Product number
- B6111
- Product name
- LuAF21934
- Packaging
- 25mg
- Price
- $304
- Updated
- 2021/12/16
Lu AF21934 Chemical Properties,Usage,Production
Biological Activity
ec50: 500 nmlu af21934 is a positive allosteric modulator of mglu4 receptors.the mglu4 receptor subtype of the group iii mglu is mainly a presynaptic auto- or hetero-receptor. its stimulation results in an inhibition of glutamatergic or gabaergic transmission and release
in vitro
lu af21934 has been identified as a brain-penetrating positive allosteric modulator of mglu4 receptors. in broad in-vitro screens, lu af21934 could potentiate the glutamate response at the mglu4 receptor with an emax=120% and a glutamate fold-shift fs=5. lu af21934 did not showed any significant affinity for 70 gpcrs at 10 μm, but acted as a weak positive allosteric modulator of mglu6 receptor, as well as an antagonist of adenosine a2a and 5-ht2b receptors [1].
in vivo
in rats, harmaline triggered tremor as manifested by an increase in the power within 9-15hz band and in the tremor index. harmaline also induced a biphasic effect on mobility, initially inhibiting the exploratory locomotor activity of rats, followed by an increase in their basic activity. lu af21934 at 0.5-5 mg/kg sc did not influence tremor but at doses of 0.5 and 2.5 mg/kg reversed harmaline-induced hyperactivity. mglu4 mrna expression was found to be high in the cerebellar cortex and low in the inferior olive [1].
target
| mGlu4 Receptor 500 nM (EC 50 ) |
References
[1] ossowska k,wardas j,berghauzen-maciejewska k,et al. lu af21934, a positive allosteric modulator of mglu4 receptors, reduces the harmaline-induced hyperactivity but not tremor in rats. neuropharmacology.2014 aug;83:28-35.
Lu AF21934 Preparation Products And Raw materials
Raw materials
Preparation Products
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