p38 MAP Kinase Inhibitor III

Product Name: p38 MAP Kinase Inhibitor III
CAS No.: 581098-48-8
Chemical Name: p38 MAP Kinase Inhibitor III
Synonyms: (S)-p38 MAPK Inhibitor III;(S)-p38 MAP Kinase Inhibitor III;p38 MAP Kinase Inhibitor III - CAS 581098-48-8 - Calbiochem;(S)-p-38 MAPK Inhibitor III,(S) p38 MAPK Inhibitor III,(S)p38 MAPK Inhibitor III;4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-2-pyridinamine;2-Pyridinamine, 4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-
CBNumber: CB53136792
Molecular Formula: C23H21FN4S
Formula Weight: 404.5
MOL File: 581098-48-8.mol

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p38 MAP Kinase Inhibitor III Property

Melting point:: 117-119 °C
Boiling point:: 589.4±60.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: +2C to +8C
solubility: DMF: 20 mg/mL; DMSO: 12 mg/mL; Ethanol: 30 mg/mL; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/mL
form: Yellow solid
pka: 9.07±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 506121
Product name: p38 MAP Kinase Inhibitor III - CAS 581098-48-8 - Calbiochem
Packaging: 1mg
Price: $189
Updated: 2025/07/31

Cayman Chemical

Product number: 19696
Product name: (S)-p38 MAPK Inhibitor III
Purity: ≥98%
Packaging: 500μg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 19696
Product name: (S)-p38 MAPK Inhibitor III
Purity: ≥98%
Packaging: 1mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 19696
Product name: (S)-p38 MAPK Inhibitor III
Purity: ≥98%
Packaging: 5mg
Price: $535
Updated: 2024/03/01

Cayman Chemical

Product number: 19696
Product name: (S)-p38 MAPK Inhibitor III
Purity: ≥98%
Packaging: 10mg
Price: $936
Updated: 2024/03/01

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p38 MAP Kinase Inhibitor III Chemical Properties,Usage,Production

Description

(S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC₅₀ = 0.90 μM in vitro). It is cell-permeable, potently blocking the release of TNF-α and IL-1β from human peripheral blood mononuclear cells (IC₅₀s = 0.37 and 0.044 μM, respectively).

Uses

p38 MAP Kinase Inhibitor III (compound 7h) is a p38 MAPK inhibitor with an 50 of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with 50 values of 0.37 μM and 0.044 μM, respectively[1].

General Description

A cell-permeable methylsulfanylimidazole compound that acts as a potent, selective, reversible, and ATP-competitive p38 MAP kinase inhibitor (IC₅₀ = 0.38 μM for p38α). Shown to effectively suppresses LPS-induced cytokine release both in vitro (IC₅₀ = 0.16 and 0.039 μM for TNF-α and IL-1β release, respectively, in human PBMC) and in vivo (ED₅₀ = 1.33 mg/kg for TNF-α release in mouse). When compared with SB 203580 (Cat. No. 559389 and 559398), it exhibits reduced inhibitory activity against cytochrome P450-2D6 isoform and, therefore, is better suited for in vivo use. A 10 mM (1 mg/247 μl) solution of p38 MAP Kinase Inhibitor III (Cat. No. 506148) in DMSO is also available.

Biochem/physiol Actions

Cell permeable: yes

IC 50

p38 MAP kinase: 0.9 μM (IC₅₀)

References

[1] Stefan A Laufer, et al. Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J Med Chem. 2003 Jul 17;46(15):3230-44. DOI:10.1021/jm030766k

p38 MAP Kinase Inhibitor III Preparation Products And Raw materials

Raw materials

Preparation Products

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p38 MAP Kinase Inhibitor III Suppliers

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581098-48-8, p38 MAP Kinase Inhibitor IIIRelated Search:

p38 MAP Kinase Inhibitor III - CAS 581098-48-8 - Calbiochem

(S)-p38 MAPK Inhibitor III

2-Pyridinamine, 4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-

(S)-p38 MAP Kinase Inhibitor III

(S)-p-38 MAPK Inhibitor III,(S) p38 MAPK Inhibitor III,(S)p38 MAPK Inhibitor III

4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-2-pyridinamine

581098-48-8