ChemicalBook > CAS DataBase List > p38 MAP Kinase Inhibitor III

p38 MAP Kinase Inhibitor III

Product Name
p38 MAP Kinase Inhibitor III
CAS No.
581098-48-8
Chemical Name
p38 MAP Kinase Inhibitor III
Synonyms
(S)-p38 MAPK Inhibitor III;(S)-p38 MAP Kinase Inhibitor III;p38 MAP Kinase Inhibitor III - CAS 581098-48-8 - Calbiochem;(S)-p-38 MAPK Inhibitor III,(S) p38 MAPK Inhibitor III,(S)p38 MAPK Inhibitor III;4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-2-pyridinamine;2-Pyridinamine, 4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-
CBNumber
CB53136792
Molecular Formula
C23H21FN4S
Formula Weight
404.5
MOL File
581098-48-8.mol
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p38 MAP Kinase Inhibitor III Property

Melting point:
117-119 °C
Boiling point:
589.4±60.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
+2C to +8C
solubility 
DMF: 20 mg/mL; DMSO: 12 mg/mL; Ethanol: 30 mg/mL; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/mL
form 
Yellow solid
pka
9.07±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
506121
Product name
p38 MAP Kinase Inhibitor III - CAS 581098-48-8 - Calbiochem
Packaging
1mg
Price
$216
Updated
2024/03/01
Cayman Chemical
Product number
19696
Product name
(S)-p38 MAPK Inhibitor III
Purity
≥98%
Packaging
500μg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
19696
Product name
(S)-p38 MAPK Inhibitor III
Purity
≥98%
Packaging
1mg
Price
$130
Updated
2024/03/01
Cayman Chemical
Product number
19696
Product name
(S)-p38 MAPK Inhibitor III
Purity
≥98%
Packaging
5mg
Price
$535
Updated
2024/03/01
Cayman Chemical
Product number
19696
Product name
(S)-p38 MAPK Inhibitor III
Purity
≥98%
Packaging
10mg
Price
$936
Updated
2024/03/01
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p38 MAP Kinase Inhibitor III Chemical Properties,Usage,Production

Description

(S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro). It is cell-permeable, potently blocking the release of TNF-α and IL-1β from human peripheral blood mononuclear cells (IC50s = 0.37 and 0.044 μM, respectively).

General Description

A cell-permeable methylsulfanylimidazole compound that acts as a potent, selective, reversible, and ATP-competitive p38 MAP kinase inhibitor (IC50 = 0.38 μM for p38α). Shown to effectively suppresses LPS-induced cytokine release both in vitro (IC50 = 0.16 and 0.039 μM for TNF-α and IL-1β release, respectively, in human PBMC) and in vivo (ED50 = 1.33 mg/kg for TNF-α release in mouse). When compared with SB 203580 (Cat. No. 559389 and 559398), it exhibits reduced inhibitory activity against cytochrome P450-2D6 isoform and, therefore, is better suited for in vivo use. A 10 mM (1 mg/247 μl) solution of p38 MAP Kinase Inhibitor III (Cat. No. 506148) in DMSO is also available.

Biochem/physiol Actions

Cell permeable: yes

p38 MAP Kinase Inhibitor III Preparation Products And Raw materials

Raw materials

Preparation Products

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p38 MAP Kinase Inhibitor III Suppliers

China 8 United States 4 Global 12
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32079
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52925
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87

581098-48-8, p38 MAP Kinase Inhibitor IIIRelated Search:


  • p38 MAP Kinase Inhibitor III - CAS 581098-48-8 - Calbiochem
  • (S)-p38 MAPK Inhibitor III
  • 2-Pyridinamine, 4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-
  • (S)-p38 MAP Kinase Inhibitor III
  • (S)-p-38 MAPK Inhibitor III,(S) p38 MAPK Inhibitor III,(S)p38 MAPK Inhibitor III
  • 4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-2-pyridinamine
  • 581098-48-8