BLU-554

Product Name: BLU-554
CAS No.: 1707289-21-1
Chemical Name: BLU-554
Synonyms: BLU-554;CS-2345;NSC 795718;Fisogatinib;BLU-554;BLU 554;BLU554, CPDB0942;BLU554(Fisogatinib);Fisogatinib (BLU 554);Fisogatinib, 10 mM in DMSO;BLU-554, 98%, a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor
CBNumber: CB53137188
Molecular Formula: C24H24Cl2N4O4
Formula Weight: 503.38
MOL File: 1707289-21-1.mol

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BLU-554 Property

Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 20 mg/mL; DMSO: 20 mg/mL; DMSO:PBS (pH 7.2) (1:2): 0.3 mg/mL; Ethanol: 0.2 mg/mL
form: A crystalline solid
pka: 13.77±0.40(Predicted)
color: White to light yellow
InChIKey: MGZKYOAQVGSSGC-DLBZAZTESA-N
SMILES: C(N[C@H]1CCOC[C@H]1NC1=NC=C2C(=N1)C=CC(C1=C(Cl)C(OC)=CC(OC)=C1Cl)=C2)(=O)C=C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22438
Product name: BLU-554
Purity: ≥95%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 22438
Product name: BLU-554
Purity: ≥95%
Packaging: 5mg
Price: $284
Updated: 2024/03/01

Cayman Chemical

Product number: 22438
Product name: BLU-554
Purity: ≥95%
Packaging: 10mg
Price: $537
Updated: 2024/03/01

Cayman Chemical

Product number: 22438
Product name: BLU-554
Purity: ≥95%
Packaging: 25mg
Price: $1041
Updated: 2024/03/01

TRC

Product number: D438290
Product name: N-[(3S,4S)-3-[[6-(2,6-Dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]tetrahydro-2H-pyran-4-yl]-2-propenamide
Packaging: 1mg
Price: $65
Updated: 2021/12/16

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BLU-554 Chemical Properties,Usage,Production

Uses

N-[(3S,4S)-3-[[6-(2,6-Dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]tetrahydro-2H-pyran-4-yl]-2-propenamide is a fibroblast growth factor receptor 4 (FGFR4) inhibitor. BLU-554

in vivo

Tissue distribution of Fisogatinib (10 mg/kg; oral gavage; for 4 hours; FVB/NRj mice) in wild-type mice is as follows; tissue concentrations decreases in the order liver > kidney > small intestine > spleen > brain. The high Fisogatinib liver-to-plasma ratio suggests there is a relatively high amount of the drug being transported into the liver^[1].

Animal Model:	Wild type male mice(FVB/NRj, 11-14?weeks of age)^[1]
Dosage:	10?mg/kg
Administration:	Oral gavage; for 4 hours (Pharmacokinetic study)
Result:	Tissue concentrations decreased in the order liver?>?kidney?>?small intestine?>?spleen?>?brain.

IC 50

FGFR4: 5 nM (IC₅₀)

BLU-554 Preparation Products And Raw materials

Raw materials

Preparation Products

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BLU-554 Suppliers

China 95 India 1 United States 7 USA 1 Global 104

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 15000803246 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 425
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 14912
Advantage: 59

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4769
Advantage: 55

Nanjing Asia Pharmaceutical Technology Co., Ltd.

Tel: +86-15251749953
Fax: -
Email: pl_pharmatech@163.com
Country: China
ProdList: 82
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Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 984
Advantage: 55

Twochem Co.Ltd

Tel: 021-021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 304
Advantage: 55

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View Lastest Price from BLU-554 manufacturers

Honest Joy Holdings Limited

Product: BLU-554 1707289-21-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.2%
Supply Ability: 100 tons
Release date: 2022-01-13

1707289-21-1, BLU-554Related Search:

3-Pyridinemethanamine, 6-(4-fluoro-1H-pyrazol-1-yl)-α-methyl-, (αR)- Cyclohexanecarboxamide, N-[(1R)-1-[6-(4-fluoro-1H-pyrazol-1-yl)-3-pyridinyl]ethyl]-1-methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]-, cis- Pralsetinib cis-Pralsetinib hydrochloride (cis-BLU-667 hydrochloride) 2-chloro-6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazoline

N-(3-{[6-(2,6-Dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino}tetrahydro-2H-pyran-4-yl)acrylamide

BLU-554

N-((3S,4S)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2H-pyran-4-yl)acrylamide

BLU554, CPDB0942

BLU-554, 98%, a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor

CS-2345

BLU-554;BLU 554

Fisogatinib (BLU 554)

Fisogatinib

2-Propenamide, N-[(3S,4S)-3-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]tetrahydro-2H-pyran-4-yl]-

BLU554(Fisogatinib)

Fisogatinib, 10 mM in DMSO

NSC 795718

1707289-21-1