Physical Form
ChemicalBook > CAS DataBase List > (S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol

(S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol

Physical Form
Product Name
(S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol
CAS No.
1454847-96-1
Chemical Name
(S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol
Synonyms
EOS-60623;-1-(5-fluoro-2-iodophenyl)ethan-1-ol;(1S)-1-(5-fluoro-2-iodophenyl)ethanol;(S)-1-(2-Iodo-5-fluorophenyl)-ethanol;(S)-1-(5-fluoro-2-iodophenyl)ehtan-1-ol;(S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol;(1S)-1-(5-FLUORO-2-IODOPHENYL)ETHAN-1-OL;(S)-5-Fluoro-2-iodo-alpha-methylbenzyl Alcohol;(S)-5-Fluoro-2-iodo-alpha-methylbenzenemethanol;Benzenemethanol, 5-fluoro-2-iodo-α-methyl-, (αS)-
CBNumber
CB53142393
Molecular Formula
C8H8FIO
Formula Weight
266.05
MOL File
1454847-96-1.mol
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(S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol Property

Boiling point:
275.7±30.0 °C(Predicted)
Density 
1.812±0.06 g/cm3(Predicted)
pka
13.80±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
CS-0078600
Product name
(S)-1-(5-Fluoro-2-iodophenyl)ethan-1-ol
Packaging
5g
Price
$105
Updated
2021/12/16
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(S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol Chemical Properties,Usage,Production

Physical Form

Solid or liquid

Uses

(S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol is an intermediate of Lorlatinib, which is an orally administered inhibitor of ALK and ROS1, two enzymes that play a role in the development of cancer.

Synthesis

(S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol is synthesised using 5'-Fluoro-2'-iodoacetophenone as a raw material by chemical reaction. The specific synthesis steps are as follows:
A solution of (-)-DIPCI (57.1 g, 178 mmol) in THF (100 ml) was cooled to -20 to -30 C. A solution of compound 1 (31 .3 g, 1 19 mmol) in THF (100 ml) was then added dropwise, via addition funnel (30 min addition). The reaction was left to warm up to RT. After 2 h, the reaction was cooled to -30 C and another portion of (-)-DIPCI (38.0 g, 1 19 mmol) was added. After 30 min, the reaction was allowed to warm to RT and after 1 h, the solvents were removed in vacuo and the residue re-dissolved in MTBE (200 ml). A solution of diethanolamine (31 g, 296 mmol) in ethanol/THF (15 ml/30 ml) was added via addition funnel, to the reaction mixture under an ice bath. The formation of a white precipitate was observed. The suspension was heated at reflux for 2 hours then cooled to room temperature, filtered and the mother liquids concentrated in vacuo. The residue was suspended in heptane/EtOAc (7:3, 200 ml) and again filtered. This procedure was repeated until no more solids could be observed after the liquids were concentrated. The final yellow oil was purified by column chromatography (eluent: cyclohexane/EtOAc- 99:1 to 96:4). The resulting colorless oil was further purified by recrystallisation from heptanes, to give alcohol compound 2 (25 g, 80% yield, 99% purity and 96% ee) as white crystals. 1H NMR (400 MHz, CDCI3) delta 7.73 (dd, 1 H), 7.32 (dd, 1 H), 6.74 (ddd, 1 H), 4.99 - 5.04 (m, 1 H), 2.01 (d, 1 H), 1.44 (d, 3 H). LCMS-ES: No ionization, Purity 99%. Chiral GC (column CP-Chirasil-DexnCB): 96% ee; Rt (minor) 17.7 minutes and Rt (major) 19.4 minutes.

(S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol Suppliers

Alfa Chemistry
Tel
1-516-6625404
Fax
1-516-927-0118
Email
support@alfa-chemistry.com
Country
United States
ProdList
9171
Advantage
60
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View Lastest Price from (S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
(S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol 1454847-96-1
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-24
Nanjing Fred Technology Co., Ltd
Product
(S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol 1454847-96-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-29
Henan Fengda Chemical Co., Ltd
Product
(S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol 1454847-96-1
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09

1454847-96-1, (S)-1-(5-fluoro-2-iodophenyl)ethan-1-olRelated Search:


  • (S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol
  • EOS-60623
  • Benzenemethanol, 5-fluoro-2-iodo-α-methyl-, (αS)-
  • (S)-1-(2-Iodo-5-fluorophenyl)-ethanol
  • (1S)-1-(5-FLUORO-2-IODOPHENYL)ETHAN-1-OL
  • -1-(5-fluoro-2-iodophenyl)ethan-1-ol
  • (1S)-1-(5-fluoro-2-iodophenyl)ethanol
  • (S)-5-Fluoro-2-iodo-alpha-methylbenzyl Alcohol
  • (S)-5-Fluoro-2-iodo-alpha-methylbenzenemethanol
  • (S)-1-(5-fluoro-2-iodophenyl)ehtan-1-ol
  • 1454847-96-1