ChemicalBook > CAS DataBase List > 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacidhydrochloride

4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacidhydrochloride

Product Name
4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacidhydrochloride
CAS No.
1646321-63-2
Chemical Name
4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacidhydrochloride
Synonyms
LNP023 hcl;EOS-61917;Iptacopan HCl;Iptacopan(lnp023);LNP023 hydrochloride;Iptacopanhydrochloride;Ipcoopam hydrochloride.;LNP023/Iptacopan hydrochloride;Iptacopan (LNP023) hydrochloride;Iptacopanhydrochloride，LNP023 hcl
CBNumber
CB53142722
Molecular Formula
C25H31ClN2O4
Formula Weight
458.98
MOL File
1646321-63-2.mol
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4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacidhydrochloride Property

storage temp. 
Store at -20°C
solubility 
DMSO : 250 mg/mL (544.69 mM; Need ultrasonic)|
form 
A solid
color 
White to off-white
Water Solubility 
Water : 50 mg/mL (108.94 mM; ultrasonic and warming and heat to 60°C)
InChIKey
SEZXOFFLNHXEJE-QHWHZDSMNA-N
SMILES
C(N1CC[C@H](OCC)C[C@H]1C1C=CC(C(=O)O)=CC=1)C1C(=CC(C)=C2NC=CC=12)OC.Cl |&1:4,9,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0131140
Product name
Iptacopan(hydrochloride)
Packaging
5mg
Price
$400
Updated
2021/12/16
ChemScene
Product number
CS-0131140
Product name
Iptacopan(hydrochloride)
Packaging
10mg
Price
$680
Updated
2021/12/16
ChemScene
Product number
CS-0131140
Product name
Iptacopan(hydrochloride)
Packaging
50mg
Price
$1900
Updated
2021/12/16
ChemScene
Product number
CS-0131140
Product name
Iptacopan(hydrochloride)
Packaging
100mg
Price
$2900
Updated
2021/12/16
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4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacidhydrochloride Chemical Properties,Usage,Production

Uses

LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor. LNP023 shows direct, reversible, and high-affinity binding to human factor B with a KD of 7.9 nM. LNP023 inhibits factor B with an IC50 value of 10 nM[1][2].

in vivo

LNP023 (20-180 mg/kg; oral administration) prevents KRN (150 μL)-induced arthritis in mice and is effective upon prophylactic and therapeutic dosing in an experimental model of membranous nephropathy in rats[2].
LNP023 exhibits moderate half-lives (T1/2; Wistar Han rats 3.4 h, beagle dogs 5.5 h) and Cmax (Wistar Han rats 410 nM, beagle dogs 2200 nM) following oral administration (rat 30 and, dog 10 mg/kg)[3].
LNP023 exhibits terminal elimination half-lives (T1/2; Wistar Han rats 7 h, beagle dogs 5.6 h) due to high plasma clearance (8, and 2 mL/min/kg respectively combined with large volumes of distribution (2.3, and 0.6 L/kg respectively) following intravenous administration (rat 1.0 and, dog 0.1 mg/kg)[3].

Animal Model:C57BL/6 mice with KRN-induced arthritis[2]
Dosage:20, 60, and 180 mg/kg
Administration:Orally gavaged; twice a day (b.i.d.) for 14 days
Result:Blocked KRN-induced arthritis.

References

[1] Dimitrios C Mastellos, et al. Expanding Complement Therapeutics for the Treatment of Paroxysmal Nocturnal Hemoglobinuria. Semin Hematol. 2018 Jul;55(3):167-175. DOI:10.1053/j.seminhematol.2018.02.002
[2] Anna Schubart, et al. Small-molecule Factor B Inhibitor for the Treatment of Complement-Mediated Diseases. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7926-7931. DOI:10.1073/pnas.1820892116
[3] Nello Mainolfi, et al. Discovery of 4-((2 S,4 S)-4-Ethoxy-1-((5-methoxy-7-methyl-1 H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases. J Med Chem. 2020 Jun 11;63(11):5697-5722. DOI:10.1021/acs.jmedchem.9b01870

4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacidhydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacidhydrochloride Suppliers

China 66 United States 5 Global 71
TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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China
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Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
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China
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4817
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CHANGZHOU PHARMACEUTICAL FACTORY
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519-88821493 18915891730
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shm@czpharma.com
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China
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Wuhan Jingkangen Biomedical Technology Co., Ltd
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13720134139 086-15871494362 13720134139
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orders@jknbiochem.com
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China
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7048
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ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185 18149758185
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sales-cpd@caerulumpharma.com
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China
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3505
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58
Bide Pharmatech Ltd.
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400-400-164-7117 18317119277
Fax
+86-21-61629029
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product02@bidepharm.com
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China
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40000
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60
Hangzhou Cheminspire Technology Co., Ltd.
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0571-89081561; 10006559855
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0571 89081561
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info@cheminspire.com
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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86249
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Cangzhou Enke Pharma-tech Co., Ltd.
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0317-5296180 15533709196
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enkepharma@126.com;sale@enkepharma.com
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Shanghai Rechem science Co., Ltd.
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1646321-63-2, 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacidhydrochlorideRelated Search:


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  • EOS-61917
  • LNP023 hcl
  • LNP023 hydrochloride
  • Iptacopan(lnp023)
  • Iptacopanhydrochloride
  • Iptacopanhydrochloride，LNP023 hcl
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  • 4-[(2S,4S)-4-Ethoxy-1-[(5-methoxy-7-methyl-1H-indol-4-yl)methyl]-2-piperidinyl]benzoic acid,hydrochloride (1:1)
  • LNP023/Iptacopan hydrochloride
  • Ipcoopam hydrochloride.
  • Iptacopan hydrochloride, 10 mM in DMSO
  • -((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacidhydrochloride
  • 1646321-63-2