ChemicalBook > CAS DataBase List > 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid

4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid

Product Name
4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid
CAS No.
1359963-68-0
Chemical Name
4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid
Synonyms
S9632;FEMA 4774;EOS-60517; FEMA 4774 NEW;4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid;3-Quinolinecarboxylic acid, 4-amino-5-[2,2-dimethyl-3-[(1-methylethyl)amino]-3-oxopropoxy]-2-methyl-;4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid Properties;Inhibitor,positive allosteric modulator,sucrose,weetness enhancer,FEMA-4774,T1R3,inhibit,FEMA4774,FEMA 4774,T1R2
CBNumber
CB53142762
Molecular Formula
C19H25N3O4
Formula Weight
359.42
MOL File
1359963-68-0.mol
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4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid Property

FEMA 
4774 | 4-AMINO-5-(3-(ISOPROPYLAMINO)-2,2-DIMETHYL-3-OXOPROPOXY)-2-METHYLQUINOLINE-3-CARBOXYLIC ACID
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 41.67 mg/mL (115.94 mM)
form 
Solid
color 
White to off-white
Odor
milky dairy
JECFA Number
2204
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
BF168573
Product name
FEMA 4774 NEW
Packaging
10mg
Price
$145
Updated
2021/12/16
AK Scientific
Product number
0902DT
Product name
3-Quinolinecarboxylicacid,4-amino-5-(2,2-dimethyl-3-((1-methylethyl)amino)-3-oxopropoxy)-2-methyl-
Packaging
10mg
Price
$245
Updated
2021/12/16
Biosynth Carbosynth
Product number
BF168573
Product name
FEMA 4774 NEW
Packaging
50mg
Price
$507.5
Updated
2021/12/16
AK Scientific
Product number
0902DT
Product name
3-Quinolinecarboxylicacid,4-amino-5-(2,2-dimethyl-3-((1-methylethyl)amino)-3-oxopropoxy)-2-methyl-
Packaging
50mg
Price
$735
Updated
2021/12/16
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4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid Chemical Properties,Usage,Production

Uses

FEMA 4774 is a positive allosteric modulator of taste receptors T1R2 and T1R3, two subunits of the human sweet taste receptor. FEMA 4774 is also used as a sucrose sweetness enhancer[1].

in vivo

FEMA 4774 (S9632) (oral gavage, 500-2000 mg/kg) does not cause a dose-dependent increase in polychromatic erythrocytes and induces micronuclei formation at dose levels up to 2000 mg/kg in Swiss albino (CD-1) mice[2].
The pharmacokinetic parameters of FEMA 4774 (S9632) in Male and Female Sprague-Dawley Rats

RouteDayDose (mg/kg)SexCmax (ng/mL)±SDTmax (hr)t1/2 (hr)AUC0last(nghr/mL)AUC0last/dose(nghr/mL/mg/kg)%F
iv11.0M2036.7±281.90.030.19330.6±58330.6-
F2625.8±679.90.030.27411.9±116.3411.9-
Oral gavage110M12.9±3.20.251.2117.9±2.31.790.54
F34.0±3.90.251.1749.2±7.84.921.19
30M90.0±23.90.330.8890.8±11.03.030.92
F62.4±25.90.421.0695.0±20.43.170.77
100M147.2±86.30.330.71176.2±73.81.760.53
F268.5±90.70.250.99341.1±81.03.410.83
Oral gavage710M16.2±3.60.500.8448.1±33.24.81-
F32.7±9.70.331.1758.9±25.45.89-
30M74.5±16.20.330.9486.0±8.72.87-
F77.1±41.70.251.39106.8±8.73.56-
100M117.9±15.30.250.72185.3±15.31.85-
F189.7±79.50.250.89278.9±79.02.79-

References

[1] Guy Servant, et al. The function and allosteric control of the human sweet taste receptor. Adv Pharmacol. 2020;88:59-82. DOI:10.1016/bs.apha.2020.01.002
[2] Amy J Arthur, et al. Toxicological evaluation of the flavour ingredient 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid. Toxicol Rep. 2015 Sep 3;2:1255-1264. DOI:10.1016/j.toxrep.2015.08.012

4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid Suppliers

China 24 United States 4 Global 28
Shanghai YuanYe Biotechnology Co., Ltd.
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1359963-68-0, 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacidRelated Search:


  • 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid
  • EOS-60517
  • FEMA 4774
  • FEMA 4774 NEW
  • 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid Properties
  • 3-Quinolinecarboxylic acid, 4-amino-5-[2,2-dimethyl-3-[(1-methylethyl)amino]-3-oxopropoxy]-2-methyl-
  • S9632
  • Inhibitor,positive allosteric modulator,sucrose,weetness enhancer,FEMA-4774,T1R3,inhibit,FEMA4774,FEMA 4774,T1R2
  • 1359963-68-0