ChemicalBook > CAS DataBase List > SHP-627

SHP-627

Product Name: SHP-627
CAS No.: 1001288-58-9
Chemical Name: SHP-627
Synonyms: FT011;SHP-627;asengeprast;FT011;SHP-627;FT011, 10 mM in DMSO;Inhibitor,FT011,FT 011,inhibit,FT-011;(E)-2-(3-(3-Methoxy-4-(prop-2-yn-1-yloxy)phenyl)acrylamido)benzoic acid;2-[[(E)-3-(3-methoxy-4-prop-2-ynoxyphenyl)prop-2-enoyl]amino]benzoic acid;(E)-2-[[3-(3-Methoxy-4-propargyloxyphenyl)-1-oxo-2-propenyl]amino]benzoic Acid;Benzoic acid, 2-[[(2E)-3-[3-methoxy-4-(2-propyn-1-yloxy)phenyl]-1-oxo-2-propen-1-yl]amino]-
CBNumber: CB53145905
Molecular Formula: C20H17NO5
Formula Weight: 351.35
MOL File: 1001288-58-9.mol

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SHP-627 Property

Boiling point:: 618.9±55.0 °C(Predicted)
Density: 1.307±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 29 mg/mL (82.54 mM)
form: Solid
pka: 3.45±0.36(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: F810410
Product name: (E)-2-[[3-(3-Methoxy-4-propargyloxyphenyl)-1-oxo-2-propenyl]amino]benzoicAcid
Packaging: 0.5mg
Price: $65
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611486
Product name: FT-011
Packaging: 5mg
Price: $324.7
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611486
Product name: FT-011
Packaging: 10mg
Price: $399.5
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611486
Product name: FT-011
Packaging: 50mg
Price: $1101.6
Updated: 2021/12/16

DC Chemicals

Product number: DC22587
Product name: FT011
Purity: >98%
Packaging: 100mg
Price: $600
Updated: 2021/12/16

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SHP-627 Chemical Properties,Usage,Production

Uses

FT011 is an anti-fibrotic agent, reduces mRNA expression of collagens I and III and inhibits collagen synthesis[1]. FT011 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

in vivo

FT011 (100 mg/kg b.i.d., p.o., for 4 weeks) improves the cardiac function and and myocardial remodeling in myocardial infarction rats^[1].

Animal Model:	Seventy male Sprague Dawley (SD) rats (weighing 200-250 g)^[1]
Dosage:	100 mg/kg
Administration:	B.I.D., p.o. on day 7 after surgery, for 4 weeks
Result:	Increased ejection fraction, fraction shortening and preload recruitable stroke work.

SHP-627 Preparation Products And Raw materials

Raw materials

Preparation Products

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SHP-627 Suppliers

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1001288-58-9, SHP-627Related Search:

SHP-627

FT011

FT011;SHP-627

Benzoic acid, 2-[[(2E)-3-[3-methoxy-4-(2-propyn-1-yloxy)phenyl]-1-oxo-2-propen-1-yl]amino]-

(E)-2-[[3-(3-Methoxy-4-propargyloxyphenyl)-1-oxo-2-propenyl]amino]benzoic Acid

(E)-2-(3-(3-Methoxy-4-(prop-2-yn-1-yloxy)phenyl)acrylamido)benzoic acid

Inhibitor,FT011,FT 011,inhibit,FT-011

asengeprast

FT011, 10 mM in DMSO

2-[[(E)-3-(3-methoxy-4-prop-2-ynoxyphenyl)prop-2-enoyl]amino]benzoic acid

1001288-58-9