CHR 6494 trifluoroacetate
- Product Name
- CHR 6494 trifluoroacetate
- CAS No.
- 1458630-17-5
- Chemical Name
- CHR 6494 trifluoroacetate
- Synonyms
- CHR 6494 TFA;CHR 6494 trifluoroacetate;CHR-6494 TFA, 10 mM in DMSO;3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine trifluoroacetate;3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine 2,2,2-trifluoroacetate;CHR-6494,inhibit,apoptosis,Haspin Kinase,NRAS mutant melanoma cells,CHR 6494,mitotic catastrophe,Inhibitor,mice,CHR6494,cancer cells,CHR6494 TFA,BRAFV600E mutant melanoma cells,CHR 6494 TFA
- CBNumber
- CB53146270
- Molecular Formula
- C18H17F3N6O2
- Formula Weight
- 406.3617896
- MOL File
- 1458630-17-5.mol
CHR 6494 trifluoroacetate Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 5326
- Product name
- CHR6494trifluoroacetate
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $167
- Updated
- 2021/12/16
- Product number
- C381288
- Product name
- CHR-6494 trifluoroacetate salt
- Packaging
- 5mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 254970
- Product name
- CHR 6494 trifluoroacetate
- Packaging
- 10mg
- Price
- $409
- Updated
- 2021/12/16
- Product number
- KIN0008605
- Product name
- CHR-6494 TRIFLUOROACETATE SALT
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $459.65
- Updated
- 2021/12/16
- Product number
- Axon2250
- Product name
- CHR6494trifluoroacetate
- Purity
- 99%
- Packaging
- 50mg
- Price
- $528
- Updated
- 2021/12/16
CHR 6494 trifluoroacetate Chemical Properties,Usage,Production
Uses
CHR6494 is a small-molecule inhibitor of histone kinase haspin, with a wide spectrum of anticancer effects.
in vivo
CHR-6494 (TFA; 50 mg/kg; i.p. in two cycles of five consecutive days for 15 days) inhibits the growth of tumor in nude mice bearing HCT-116 human colorectal cancer cells[1].
CHR-6494 (TFA; 20 mg/kg; intraperitoneal injection for 15 consecutive days) inhibits the tumor growth in nude mice bearing MDA-MB-231 xenograft tumors[3].
| Animal Model: | Male 4-5 weeks old athymic nu/nu mice harboring HCT-116 cells xenograft tumor with a tumor volume of 200mm3[1] |
| Dosage: | 50mg/kg (diluted in a solution of 10% DMSO/20% 2-hydroxypropyl-b-cyclodextrin) |
| Administration: | i.p. in two cycles of five consecutive days for 15 days |
| Result: | Dose-dependent tumor growth inhibition was demonstrated. Did not change the body weight of mice. |
| Animal Model: | 4‐week‐old female nude mice bearing MDA-MB-231 xenograft tumors |
| Dosage: | 20 mg/kg in a final formulation in 10% DMSO/20% 2‐hydroxypropyl‐β‐cyclodextrin |
| Administration: | i.p. for 15 consecutive days |
| Result: | Inhibited the tumor volume and weight compared with the control group in nude mice bearing MDA-MB-231 xenograft tumors. Enhanced the tumor volume and weight inhibition of MLN8237 (20 mg/kg; p.o.) in vivo. |
IC 50
haspin: 2 nM (IC50)
storage
Store at +4°C
CHR 6494 trifluoroacetate Preparation Products And Raw materials
Raw materials
Preparation Products
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