(25S)-Δ7-Dafachronic Acid

Product Name: (25S)-Δ7-Dafachronic Acid
CAS No.: 949004-12-0
Chemical Name: (25S)-Δ7-Dafachronic Acid
Synonyms: (25S)-Δ7-Dafachronic Acid;(25S)-Delta(7)-dafachronic acid;(5α,25S)-3-oxo-cholest-7-en-26-oicacid;Cholest-7-en-26-oic acid, 3-oxo-, (5α,25S)-;(25S)-delta-7-Dafachronic acid,(25S) delta7 Dafachronic acid,(25S)delta7Dafachronic acid;(2S,6R)-6-[(5S,9R,10S,13R,14R,17R)-10,13-dimethyl-3-oxo-1,2,4,5,6,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-methylheptanoic acid
CBNumber: CB53152417
Molecular Formula: C27H42O3
Formula Weight: 414.62
MOL File: 949004-12-0.mol

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(25S)-Δ7-Dafachronic Acid Property

storage temp.: Store at -20°C
solubility: DMF: 5 mg/ml; DMSO: 2.5 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
form: A crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 14101
Product name: (25S)-Δ7-Dafachronic Acid
Purity: ≥95%
Packaging: 100μg
Price: $289
Updated: 2024/03/01

Cayman Chemical

Product number: 14101
Product name: (25S)-Δ7-Dafachronic Acid
Packaging: 500μg
Price: $1156
Updated: 2024/03/01

Cayman Chemical

Product number: 14101
Product name: (25S)-Δ7-Dafachronic Acid
Packaging: 1mg
Price: $2168
Updated: 2024/03/01

AK Scientific

Product number: 0201DB
Product name: (25S)-delta(7)-Dafachronicacid
Packaging: 1mg
Price: $2604
Updated: 2021/12/16

Adipogen Life Sciences

Product number: AG-CN2-0014-C100
Product name: (25S)-Δ7-Dafachronicacid
Purity: ≥95%(HPLC)
Packaging: 100μg
Price: $270
Updated: 2021/12/16

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(25S)-Δ7-Dafachronic Acid Chemical Properties,Usage,Production

Description

During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival. DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans. DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. (25S)-Δ⁷-Dafachronic acid is a sterol-derived hormone that acts as a ligand of DAF-12 with an EC₅₀ value of 23 nM. At 50 nM, (25S)-Δ⁷-Dafachronic acid inhibits the dauer-promoting activity of DAF-12, blocking the formation of infective larvae in several parasitic nematodes in favor of reproductive maturation to adults. Thus, selective ligand modulators of DAF-12 are a potential therapeutic approach to stop larvae progression during parasitic infection.

Definition

ChEBI: A Delta7-dafachronic acid that has S configuration at position 25 (the carbon attached to the carboxy group).

storage

+4°C

(25S)-Δ7-Dafachronic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(25S)-Δ7-Dafachronic Acid Suppliers

China 10 United States 4 Global 14

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
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Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6870
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TargetMol Chemicals Inc.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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MedBioPharmaceutical Technology Inc

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Email: order@med-bio.cn
Country: China
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amyjetsci

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TargetMol Chemicals Inc.

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Country: China
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Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52927
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949004-12-0, (25S)-Δ7-Dafachronic AcidRelated Search:

(25S)-Δ7-Dafachronic Acid

(25S)-Delta(7)-dafachronic acid

(2S,6R)-6-[(5S,9R,10S,13R,14R,17R)-10,13-dimethyl-3-oxo-1,2,4,5,6,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-methylheptanoic acid

Cholest-7-en-26-oic acid, 3-oxo-, (5α,25S)-

(25S)-delta-7-Dafachronic acid,(25S) delta7 Dafachronic acid,(25S)delta7Dafachronic acid

(5α,25S)-3-oxo-cholest-7-en-26-oicacid

949004-12-0