CAY10678

Product Name: CAY10678
CAS No.: 1268709-57-4
Chemical Name: CAY10678
Synonyms: CAY10678;CAY10678 Exclusive;CAY10678, 10 mM in DMSO;N-Cyclopentyl-1-(1-isopropyl-5,6-dimethyl-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxamide;N-Cyclopentyl-1-[5,6-dimethyl-1-(1-methylethyl)-1H-benzimidazol-2-yl]-4-piperidinecarboxamide;4-Piperidinecarboxamide, N-cyclopentyl-1-[5,6-dimethyl-1-(1-methylethyl)-1H-benzimidazol-2-yl]-;1-(1-isopropyl-5,6-dimethyl-1H- benzoimidazol-2-yl)-piperidine-4-carboxylic acid cyclopentylamide
CBNumber: CB53152578
Molecular Formula: C23H34N4O
Formula Weight: 382.54
MOL File: 1268709-57-4.mol

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CAY10678 Property

storage temp.: Store at -20°C
solubility: DMF: 15 mg/ml; DMSO: 5 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS (pH 7.2) (1:8): 0.1 mg/ml
form: A crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15129
Product name: CAY10678
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 15129
Product name: CAY10678
Purity: ≥98%
Packaging: 5mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 15129
Product name: CAY10678
Purity: ≥98%
Packaging: 10mg
Price: $239
Updated: 2024/03/01

TRC

Product number: C989430
Product name: N-Cyclopentyl-1-(1-isopropyl-5,6-dimethyl-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxamide
Packaging: 10mg
Price: $415
Updated: 2021/12/16

AK Scientific

Product number: 2441DT
Product name: CID67033699
Packaging: 5mg
Price: $459
Updated: 2021/12/16

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CAY10678 Chemical Properties,Usage,Production

Uses

N-Cyclopentyl-1-(1-isopropyl-5,6-dimethyl-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxamide is a benzoimidazole that potently inhibits human and rat recombinant mPGES-1.

in vivo

mPGES-1-IN-2 (compound III) (10-100 mg/kg; ip; single dose) effectively inhibits global prostaglandin production in a mouse model of air sac inflammation induced by 1% λ-Carrageenan (HY-N9470). synthesis and reduce cell migration^[1].

Animal Model:	1% Carrageenan stimulated mouse air pouch model^[1]
Dosage:	10, 50, 100 mg/kg
Administration:	ip; single dose after modeling: use 3 mL of sterile-filtered air was injected sub-cutaneously into the interscapular region of mice; triggered in the pouch 24 h later by the injection of a 1 ml solution of λ-carrageenan (1%) in saline.
Result:	Had no effect on inflammatory exudate volume but dose-dependently reduced cell migration. Resulted in a decrease in PGE2 synthesis, it does not affect changes in other prostaglandin levels, but leads to an overall downregulation of prostaglandin synthesis.

storage

Store at -20°C

CAY10678 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10678 Suppliers

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1268709-57-4, CAY10678Related Search:

CAY10678

N-Cyclopentyl-1-(1-isopropyl-5,6-dimethyl-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxamide

CAY10678 Exclusive

1-(1-isopropyl-5,6-dimethyl-1H- benzoimidazol-2-yl)-piperidine-4-carboxylic acid cyclopentylamide

N-Cyclopentyl-1-[5,6-dimethyl-1-(1-methylethyl)-1H-benzimidazol-2-yl]-4-piperidinecarboxamide

4-Piperidinecarboxamide, N-cyclopentyl-1-[5,6-dimethyl-1-(1-methylethyl)-1H-benzimidazol-2-yl]-

CAY10678, 10 mM in DMSO

1268709-57-4