R-7050

Product Name: R-7050
CAS No.: 303997-35-5
Chemical Name: R-7050
Synonyms: R-7050;R-7050;R 7050;R7050;TNF-α Antagonist III;TNF-α Antagonist III;TNF-alpha Antagonist III, R-7050;8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline;[1,2,4]Triazolo[4,3-a]quinoxaline, 8-chloro-4-(phenylthio)-1-(trifluoromethyl)-;R 7050,Inhibitor,R7050,inhibit,TNFR,Tumor Necrosis Factor Receptor,TNF Receptor,R-7050
CBNumber: CB53152725
Molecular Formula: C16H8ClF3N4S
Formula Weight: 380.77
MOL File: 303997-35-5.mol

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R-7050 Property

Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: insoluble in H2O; ≥17.67 mg/mL in DMSO; ≥2.2 mg/mL in EtOH with gentle warming and ultrasonic
form: crystalline solid
pka: -3.70±0.30(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 654257
Product name: TNF-α Antagonist III, R-7050 - CAS 303997-35-5 - Calbiochem
Packaging: 10mg
Price: $201
Updated: 2024/03/01

Cayman Chemical

Product number: 16870
Product name: R-7050
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16870
Product name: R-7050
Purity: ≥95%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 16870
Product name: R-7050
Purity: ≥95%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 16870
Product name: R-7050
Purity: ≥95%
Packaging: 25mg
Price: $305
Updated: 2024/03/01

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R-7050 Chemical Properties,Usage,Production

Uses

R 7050 is a cell permeable TNF-α receptor antagonist.

Biological Activity

ec50: 0.631 μm by tnf-α by icam-1 elisa assayr-7050 is a tnf-α receptor signaling antagonist.tnf-α induces biological activity throgh stimulation of the tumor necrosis factor receptor. although plenty of pre-clinical and clinical evidence suggests a detrimental role, small molecule tnf-αsignaling pathway inhibitors remain largely unexplored in the context of a brain hemorrhage.

in vitro

r-7050 was identified as a selective inhibitot of tnf-α induced cellular signaling by using differential library screening. unlike biologic tnf inhibitors directly binding tnf-α, r-7050 could not affect binding of tnf-α to tnfr. in contrast, r-7050 was able to selectively inhibit the association of tnf receptor with intracellular adaptor molecules [1].

in vivo

in previous animal study, r-7050 was tested to attenuate neurovascular injury after intracerebral hemorrhage (ich) in mice. results showed that up to 2h post-injury administration of r-7050 was able to significantly reduce blood-brain barrier opening and attenuate edema development at 24h post-ich. in addition, neurological outcomes were also improved over the first 3 days after injury. whereas, r-7050 was not found to be albe to reduce hematoma volume, indicating the beneficial effects of tnfr inhibition were downstream of clot formation/resolution [2].

storage

Store at +4°C

References

[1] gururaja tl, yung s, ding r, huang j, zhou x, mclaughlin j, daniel-issakani s, singh r, cooper rd, payan dg, masuda es, kinoshita t. a class of small molecules that inhibit tnfalpha-induced survival and death pathways via prevention of interactions between tnfalphari, tradd, and rip1. chem biol. 2007 oct;14(10):1105-18.
[2] king md, alleyne ch jr, dhandapani km. tnf-alpha receptor antagonist, r-7050, improves neurological outcomes following intracerebral hemorrhage in mice. neurosci lett. 2013 may 10;542:92-6.

R-7050 Preparation Products And Raw materials

Raw materials

Preparation Products

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R-7050 Suppliers

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303997-35-5, R-7050Related Search:

R-7050

R-7050;R 7050;R7050

8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline

TNF-α Antagonist III

[1,2,4]Triazolo[4,3-a]quinoxaline, 8-chloro-4-(phenylthio)-1-(trifluoromethyl)-

TNF-alpha Antagonist III, R-7050

TNF-α Antagonist III

R 7050,Inhibitor,R7050,inhibit,TNFR,Tumor Necrosis Factor Receptor,TNF Receptor,R-7050

303997-35-5