STO-609 (acetate)
- Product Name
- STO-609 (acetate)
- CAS No.
- 1173022-21-3
- Chemical Name
- STO-609 (acetate)
- Synonyms
- CS-2405;PubChem ID: 16760660;STO-609;STO 609;STO609;7-oxo-7H-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinoline-3-carboxylic acid;7H-Benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, 7-oxo-, acetate (1:1);7-Oxo-7H-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinoline-3-carboxylic Acid Acetate (1:1)
- CBNumber
- CB53152750
- Molecular Formula
- C21H14N2O5
- Formula Weight
- 374.35
- MOL File
- 1173022-21-3.mol
STO-609 (acetate) Property
- Melting point:
- >300 °C
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (up to 10 mg/ml).
- form
- Yellow solid.
- color
- Yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S1318
- Product name
- STO-609-acetic acid
- Purity
- ≥95%(HPLC),solid
- Packaging
- 5mg
- Price
- $204
- Updated
- 2024/03/01
- Product number
- S1318
- Product name
- STO-609-acetic acid
- Purity
- ≥95% (HPLC), solid
- Packaging
- 25MG
- Price
- $643
- Updated
- 2024/03/01
- Product number
- 15325
- Product name
- STO-609 (acetate)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 15325
- Product name
- STO-609 (acetate)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 15325
- Product name
- STO-609 (acetate)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $153
- Updated
- 2024/03/01
STO-609 (acetate) Chemical Properties,Usage,Production
Description
STO-609 (1173022-21-3) is a selective inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki = 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively).1 Binds to the? ATP-binding site.2 Displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK. Important tool for probing distinct CaMK pathways in LTP.3 Reduces starvation-induced autophagosomal membrane formation.4 Reverses age-associated decline in bone mass.5 Stimulates osteoblast formation, inhibits osteoclast differentiation.6
Uses
STO-609 is a cell-permeable inhibitor of calcium/calmodulin-dependent kinase kinases (CaMKK) isoforms CaMKKα and CaMKKβ. It is used to evaluate the action of CaMKK isoforms both in vitro and in cells.
General Description
STO-609 reduces tumorigenicity of liver cancer cells in vivo. TO-609 reduces the activation of AMP (adenosine monophosphate)-activated protein kinase (AMPK) by ionomycin in a dose dependant manner.
Biochem/physiol Actions
Selective Ca2+/Calmodulin-dependent protein kinase kinase (CaM-KK) antagonist. Inhibits CamKKa and CaMKKb with Ki = 80 and 15 ng/mL, respectively. Does not inhibit downstream CaM kinases (CaMKI and CaMKIV).
storage
Room temperature (desiccate)
References
1) Tokumitsu?et al. (2002), STO-609, a Specific Inhibitor of the Ca2+/Calmodulin-dependent Protein Kinase Kinase;?J. Biol. Chem. 277 15813 2) Tokumitsu?et al. (2003) A single amino acid difference between alpha and beta Ca2+/calmodulin-dependent protein kinase kinase dictates sensitivity to the specific inhibitor, STO-609;?J. Biol. Chem. 278 10908 3) Redondo et al. (2010) Synaptic tagging and capture: differential role of distinct calcium/calmodulin kinases in protein synthesis-dependent long-term potentiation;?J. Neurosci. 30 4981 4) Pfisterer et al. (2011) Ca+2/calmodulin –dependent kinase (CaMK) signaling via CaMKI and AMP-activated protein kinase contributes to the regulation of WIPI-1 ar the onset of autophagy; Mol. Pharmacol. 80 1066 5) Pritchard et al. (2015) Inhibition of CaMKK2 reverses age-associated decline in bone mass; Bone, 75 120 6)Cary?et al. (2013) Inhibition of Ca+2/Calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation;?J. Bone Miner. Res. 28 1599 7) Matsukawa et al. (2017) Upregulation of skeletal muscle PGC-1α through the elevation of cyclic AMP levels by Cyanidin-3-glucoside enhances exercise performance; Sci. Rep., 7 44799
STO-609 (acetate) Preparation Products And Raw materials
Raw materials
Preparation Products
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