ChemicalBook > CAS DataBase List > S49076

S49076

Product Name
S49076
CAS No.
1265965-22-7
Chemical Name
S49076
Synonyms
S49076;CS-2684;S4 9076;S4-9076;FGFR,S49076,Fibroblast growth factor receptor,inhibit,c-Met/HGFR,S 49076,Inhibitor,S-49076;3-((3-((4-(Morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione;(Z)-3-((3-((4-(morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione;2,4-Thiazolidinedione, 3-[[2,3-dihydro-3-[[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene]-2-oxo-1H-indol-5-yl]methyl]-
CBNumber
CB53159461
Molecular Formula
C22H22N4O4S
Formula Weight
438.5
MOL File
1265965-22-7.mol
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S49076 Property

storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 31 mg/mL (70.70 mM)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-6191
Product name
S49076
Purity
98.62%
Packaging
2mg
Price
$72
Updated
2021/12/16
ChemScene
Product number
CS-6191
Product name
S49076
Purity
98.62%
Packaging
5mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-6191
Product name
S49076
Purity
98.62%
Packaging
10mg
Price
$156
Updated
2021/12/16
ChemScene
Product number
CS-6191
Product name
S49076
Purity
98.62%
Packaging
50mg
Price
$540
Updated
2021/12/16
ChemScene
Product number
CS-6191
Product name
S49076
Purity
98.62%
Packaging
100mg
Price
$972
Updated
2021/12/16
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S49076 Chemical Properties,Usage,Production

Biological Activity

S49076 is a novel and potent inhibitor of Met (c-Met), AXL/MER and FGFR1/2/3 with IC50 below 20 nM.

in vivo

S49076 effectively inhibits the phosphorylation of MET, AXL and FGFRs in cells, and inhibits their downstream signaling pathways in vitro and in vivo. In cellular models, it inhibits MET and FGFR2-dependent gastric cancer cells, prevents MET-driven migration of lung cancer cells, and inhibits colony formation of liver cancer cells expressing FGFR1/2 and AXL. S49076 inhibits cell viability, motile, three-dimensional colony formation of cancer cells expressing MET, AXL or FGFRs.

in vivo

S49076 has significant antitumor activity in MET- and FGFR-dependent tumor grafts. It is highly distributed in tumors, with a half-life of approximately 7 hours in tumors and less than 2 hours in blood at a dose of 3.125 mg/kg. At doses above 6.25 mg/kg, more than 50% of MET phosphorylation was inhibited for 16 hours. S49076 was also active in a bevacizumab-resistant model, and in combination with bevacizumab, completely inhibited the growth of colon cancer xenografts.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> Axl
(Cell-free assay)
TargetValue
Met
(Cell-free assay)		 1 nM
Mer
(Cell-free assay)		 2 nM
7 nM
FGFR3
(Cell-free assay)		 15 nM
FGFR2
(Cell-free assay)		 17 nM

S49076 Preparation Products And Raw materials

Raw materials

Preparation Products

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S49076 Suppliers

China 44 India 1 United States 5 Global 50
ChemShuttle, Inc.
Tel
0510-83588313-802 18800520310;
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sales@chemshuttle.com
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China
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Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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sales@meilune.com
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China
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4663
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58
Shanghai Topbiochem Technology Co., Ltd
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021-58170097
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info@topbiochem.com
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China
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58
Guangzhou Isun Pharmaceutical Co., Ltd
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020-39119399 18927568969
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020-39119999
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isunpharm@qq.com
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55
Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
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022-23754520
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klq@cw-bio.com
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ShangHai Biochempartner Co.,Ltd
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17754423994 17754423994
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QQ:2853530913
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Shanghai Chaolan Chemical Technology Center
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QQ:65489617 15618227136
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Amadis Chemical Company Limited
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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DC Chemicals
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career henan chemical co
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Absin Bioscience Inc.
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chenjw@absin.cn
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Energy Chemical
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Nantong Feiyu Biological Technology CO.,LTD
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InvivoChem
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TargetMol Chemicals Inc.
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RD International Technology Co., Limited
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View Lastest Price from S49076 manufacturers

Career Henan Chemical Co
Product
S49076 1265965-22-7
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20kg
Release date
2019-12-23

1265965-22-7, S49076Related Search:


  • S49076
  • CS-2684
  • S4 9076;S4-9076
  • 2,4-Thiazolidinedione, 3-[[2,3-dihydro-3-[[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene]-2-oxo-1H-indol-5-yl]methyl]-
  • FGFR,S49076,Fibroblast growth factor receptor,inhibit,c-Met/HGFR,S 49076,Inhibitor,S-49076
  • (Z)-3-((3-((4-(morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione
  • 3-((3-((4-(Morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione
  • 1265965-22-7