ChemicalBook > CAS DataBase List > Fosravuconazole bis(L-lysine
Fosravuconazole bis(L-lysine
- Product Name
- Fosravuconazole bis(L-lysine
- CAS No.
- 1035654-66-0
- Chemical Name
- Fosravuconazole bis(L-lysine
- Synonyms
- Sarecycline Base;Sarecycline free base;Sarecycline Impurity 5;PQJQFLNBMSCUSH-SBAJWEJLSA-N;Fosravuconazole bis(L-lysine;Minocycline Impurity 27 (Sarecycline);2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-7-[(methoxymethylamino)methyl]-1,11-dioxo-, (4S,4aS,5aR,12aS)-
- CBNumber
- CB53159906
- Molecular Formula
- C24H29N3O8
- Formula Weight
- 487.5
- MOL File
- 1035654-66-0.mol
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Fosravuconazole bis(L-lysine Property
- Boiling point:
- 787.0±70.0 °C(Predicted)
- Density
- 1.53±0.1 g/cm3(Predicted)
- pka
- 4.50±1.00(Predicted)
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Fosravuconazole bis(L-lysine Chemical Properties,Usage,Production
Uses
Sarecycline-d6 Hydrochloride is a labelled analogue of Sarecycline Hydrochloride(S140525), which is a substituted tetracycline compound used for treatment of bacterial infections and neoplasms.
in vivo
Sarecycline hydrochloride (0.33-9 mg/kg; i.v.) show potent activity against S. aureus in a murine neutropenic thigh infection model[1].
Sarecycline can inhibit S. aureus (PD50=0.25 mg/kg), but has no significant effect on E. coli even at the highest dose (>40 mg/kg) in CD-1 mice model of systemic (intraperitoneal) infection[6].
Sarecycline (1-150mg/kg; Intraperitoneal injection; Single dose) shows anti-inflammatory activity in Sprague Dawley rats model[6].
| Animal Model: | Carrageenan-induced footpad edema male Sprague Dawley rats model[6] |
| Dosage: | 1 mg/kg, 5 mg/kg ,10 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg,100 mg/kg, 150 mg/kg |
| Administration: | Intraperitoneal injection (i.p.); Single dose. Before a subplantar injection of sterile 1 mg/0.1 mL carrageenan solution in the right hind paw. |
| Result: | Reduced inflammation to 55.7% and 53.1%, respectively, at doses of 75 mg/kg and 100 mg/kg compared to baseline. |
| Animal Model: | Carrageenan-induced footpad edema male Sprague Dawley rats model[6] |
| Dosage: | 0.33, 1, 3, or 9mg/kg |
| Administration: | Intravenously |
| Result: | Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32mg/kg, respectively. |
IC 50
Tetracycline
Fosravuconazole bis(L-lysine Preparation Products And Raw materials
Raw materials
Preparation Products
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