Tafamidis Meglumine

ChemicalBook > CAS DataBase List > Tafamidis Meglumine

Product Name: Tafamidis Meglumine
CAS No.: 951395-08-7
Chemical Name: Tafamidis Meglumine
Synonyms: PF06291826;PF-06291826;cas 594839-88-0;afamidis Meglumine;Tafamidis Meglumine;Tafamidis-meglumine API;Tafamidis meglumine (Fx1006, PF06291826);tafamidis meglumine,Inhibitor,Tafamidis,inhibit;TAFAMIDIS;CAS 594839-88-0;PF-06291826;PF06291826;6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole meglumine
CBNumber: CB53159986
Molecular Formula: C21H24Cl2N2O8
Formula Weight: 503.33
MOL File: 951395-08-7.mol

Less

Tafamidis Meglumine Property

Melting point:: 195 - 198°C
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: DMSO (Sparingly, Heated, Sonicated)
form: Solid
color: White to Off-White

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb573018
Product name: Tafamidis meglumine
Purity: >98%
Packaging: 100mg
Price: $615.4
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573018
Product name: Tafamidis meglumine
Purity: >98%
Packaging: 250mg
Price: $1060.8
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573018
Product name: Tafamidis meglumine
Purity: >98%
Packaging: 1g
Price: $2097.8
Updated: 2021/12/16

DC Chemicals

Product number: DC12377
Product name: Tafamidismeglumine
Purity: >98%
Packaging: 100mg
Price: $400
Updated: 2021/12/16

DC Chemicals

Product number: DC12377
Product name: Tafamidismeglumine
Purity: >98%
Packaging: 1g
Price: $1400
Updated: 2021/12/16

Less

Tafamidis Meglumine Chemical Properties,Usage,Production

Description

In November 2011, the European Commission approved tafamidis meglumine (Fx-1006A, PF-06291826) for the treatment of transthyretin familial amyloid polyneuropathy (TTR-FAP) in adult patients with stage 1 symptomatic polyneuropathy. Tafamidis stabilizes both the wild type and mutant forms of TTR tetramer and prevents tetramer dissociation by noncooperatively binding to the two thyroxine binding sites. Tafamidis is the first approved medicine for TTR-FAP. The Kd values for tafamidis for the two thyroxine binding sites on TTR, as determined by isothermal titration calorimetry, were 3 nM and 278 nM, respectively. In another in vitro study using wild type TTR, V30M mutant TTR, and V122I mutant TTR, it was shown that tafamidis inhibited fibril formation in a concentration-dependent manner reaching EC₅₀ at a tafamidis:TTR stoichiometry of <1 (EC₅₀ was in the range of 2.7–3.2 μM, corresponding to a tafamidis:TTR stoichiometry range of 0.75–0.9). Tafamidis has been synthesized by coupling 4-amino-3- hydroxybenzoic acid with 3,5-dichlorobenzoyl chloride followed by dehydration using p-toluenesulfonic acid.

Originator

Scripps Research Institute (United States)

Uses

Tafamidis Meglumine is used as a potential therapeutics for COVID-19 and related viral infections

Definition

ChEBI: Tafamidis meglumine is an organoammonium salt obtained by combining tafamidis with one molar equivalent of 1-deoxy-1-(methylamino)-D-glucitol. Used for the amelioration of transthyretin-related hereditary amyloidosis. It has a role as a central nervous system drug. It contains a tafamidis(1-).

brand name

Vyndaqel

Clinical Use

Tafamidis meglumine is a transthyretin amyloid inhibitor that was approved for the treatment of transthyretin amyloid polyneuropathy (ATTR-PN) and transthyretin familial amyloid polyneropathy (TTR-FAP). These diseases represent a rare autosomal neurodegenerative disorder characterized by autonomic, sensory and motor impairment which are typically fatal. Tafamidis was discovered at The Scripps Research Institute and developed by Pfizer.

Synthesis

Numerous synthetic routes have been reported including the use of direct CH activation to form the key biaryl bond. Although only reported on small scale, the most likely production route is detailed in the scheme.

Condensation of methyl 4-amino-3-hydroxybenzoic acid (154) with 3,5-dichlorobenzoyl chloride (155) in refluxing pyridine gave intermediate amide 156 which underwent cycylization upon treatment with p-TsOH in refluxing toluene producing benzoxazole 157. Saponification of the methyl ester with LiOH (aq.) afforded tafamidis. The free acid was treated with N-methyl-D-glutamine to provide tafamidis meglumine (XXIV) in 82% yield.

Tafamidis Meglumine Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Tafamidis Meglumine Suppliers

China 50 India 12 United States 3 Global 65

SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.

Tel: 021-34666753 13311639313
Fax: +86-21-34979012
Email: info@shyrchem.com
Country: China
ProdList: 570
Advantage: 55

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4153
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-59402396 13419635609
Fax: 027-83989310
Email: 13419635609@163.com
Country: China
ProdList: 1992
Advantage: 55

Wuhan Wsem Biological Co., Ltd.

Tel: 027-83778876 13667159345
Fax: 027-83778876
Email: 13667159345@163.com
Country: China
ProdList: 1942
Advantage: 55

Wellman Pharmaceutical Group Limited

Tel: 027-027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 3979
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-83778895 18602735115
Fax: 027-51119224
Email: 18602735115@163.com
Country: China
ProdList: 1999
Advantage: 64

Abydos Scientific

Tel: 025-84767922 18936879710
Email: sales@abydoscientific.com
Country: China
ProdList: 1029
Advantage: 58

Changzhou Yongfeng Biomedicine Co. Ltd.

Tel: 15006117673
Fax: 2973592490@.com
Email: 2973592490@qq.com
Country: China
ProdList: 310
Advantage: 58

Taizhou Crene Biotechnology Co. Ltd.

Tel: 0576-88813233 13396860566
Email: sales@pharm-intermediates.com
Country: China
ProdList: 2013
Advantage: 58

Hebei Mojin Biotechnology Co., Ltd

Tel: +8613288715578
Email: sales@hbmojin.com
Country: China
ProdList: 12471
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: 0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25363
Advantage: 58

Guangzhou TongYi biochemistry technology Co.,LTD

Tel: +8613073028829
Email: mack@tongyon.com
Country: China
ProdList: 2996
Advantage: 58

Shijiazhuang Dingmin pharmaceutical Sciences Co.,Ltd

Tel: +86-0311-67591193 +86-15030197620
Fax: QQ:2786999724
Email: sales02@dingminpharma.com
Country: China
ProdList: 300
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9414
Advantage: 58

Shanghai Yanze Chemical Co., Ltd.

Tel: 021-13773155751 19901447308
Email: 260924549@qq.com
Country: China
ProdList: 8709
Advantage: 58

Shanghai Luofa Biochemical Technology Co., Ltd.

Tel: 021-51111890 15317326293
Email: sales@molnova.com
Country: China
ProdList: 4196
Advantage: 58

SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD

Tel: 0755-0755-0755-83725350 13380397412
Fax: 0755-28094224
Email: 3001280422@qq.com
Country: China
ProdList: 9954
Advantage: 58

Wuhan Wiseman Bioengineering Co.,Ltd

Tel: 027-59506022 13419526507
Fax: 027-59506022
Email: 13419526507@163.com
Country: China
ProdList: 2932
Advantage: 58

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
Email: 2936752263@qq.com
Country: China
ProdList: 7955
Advantage: 58

Hubei Zhonglong Kangsheng fine chemical Co.,Ltd

Tel: 027-83850299 15827297403
Fax: Q2315383731
Email: 2315383731@qq.com
Country: China
ProdList: 1050
Advantage: 58

Wuhan Linglingjiu Biotechnology Co., Ltd

Tel: 15623309010
Email: 1287744812@qq.com
Country: China
ProdList: 1657
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-81124267 15229202216
Fax: 029-88380327
Email: 1073@dideu.com
Country: China
ProdList: 10011
Advantage: 58

Anqing Rong Chuang Biological Technology Co., Ltd.

Tel: 15001988657
Email: 1367753897@qq.com
Country: China
ProdList: 943
Advantage: 58

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 7977
Advantage: 58

Wuhan Augda Biotechnology Co., Ltd

Tel: 15071299552
Fax: QQ:262933239
Email: 262933239@qq.com
Country: China
ProdList: 6637
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6712
Advantage: 58

Jiangxi ravel Biotechnology Co.,Ltd

Tel: 400-880-2824 15608648206
Email: 1987516016@qq.com
Country: China
ProdList: 2608
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: +86-027-59232304 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9892
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24023
Advantage: 58

Hubei wei shi reagent group ltd., company

Tel: 027-59105166 13125137732
Email: 2853863890@qq.com
Country: China
ProdList: 2941
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29803
Advantage: 58

Pushan Industry (Shaanxi) Co., Ltd.

Tel: 029-81310890 13571859809
Email: info@pushanshiye.com
Country: China
ProdList: 10004
Advantage: 58

Xianning Shen Lan Biomedical Research and Development Co., Ltd.

Tel: 18171815831
Email: 1341138380@qq.com
Country: China
ProdList: 2780
Advantage: 58

Hangzhou Yaoruiyicheng Biological Medicine Co., Ltd

Tel: 18072846723
Email: caigou1@witofly.com
Country: China
ProdList: 18926
Advantage: 58

Shijiazhuang Kangxi Biotechnology Limited

Tel: 13803336640
Email: 3501227372@qq.com
Country: China
ProdList: 1247
Advantage: 58

Wuhan Acumen Bio-Technology Co.,ltd

Tel: 027-027-16602739303 16602739303
Email: 673003916@qq.com
Country: China
ProdList: 2887
Advantage: 58

Shenzhen Xingyue Biotechnology Co., Ltd

Tel: 18124513697; 18124513697
Fax: 18822823697
Email: jjj18822823697@163.com
Country: China
ProdList: 1410
Advantage: 58

Shanghai Yanze Chemical Co., Ltd

Tel: 021-13621551597 19975051755
Email: 260924549@qq.com
Country: China
ProdList: 6455
Advantage: 58

Shanghai jerryxing Biomedical Technology Co., Ltd

Tel: 17721492509
Email: 643638326@qq.com
Country: China
ProdList: 5347
Advantage: 58

Changsha Fuzhen Biotechnology Co.，LTD

Tel: 0731-18670069958 18670069958
Email: 184792226@qq.com
Country: China
ProdList: 3007
Advantage: 58

Suzhou ARTK Medchem Co., Ltd.

Tel: +86-512-68323967 +86-18015559028
Email: sales1@artkmedchem.com
Country: China
ProdList: 8920
Advantage: 58

Henan Fengda Chemical Co., Ltd

Tel: +86-371-86557731 +86-13613820652
Fax: 86-0371-86557731
Email: info@fdachem.com
Country: China
ProdList: 18229
Advantage: 58

Wuhan Topule Biopharmaceutical Co., Ltd

Tel: +8618327326525
Email: masar@topule.com
Country: China
ProdList: 8474
Advantage: 58

Hebei Guanlang Biotechnology Co., Ltd.

Tel: +86-19930503259 +86-19930503259
Email: cherry@crovellbio.com
Country: China
ProdList: 18451
Advantage: 58

Nanjing Doge Biomedical Technology Co., Ltd

Tel: +86-25-58227606 +86-15305155328
Email: sales@dogechemical.com
Country: China
ProdList: 4128
Advantage: 58

Jiangxi Huihe Chemical Co., Ltd.

Tel: +86-19189228086 +8618858568638
Email: wuzhouding@huihecrop.com
Country: China
ProdList: 886
Advantage: 58

Chemia Biotechnology（Shanghai） Co., Ltd

Tel: +8613816753574
Email: info@chemia-pharm.com
Country: CHINA
ProdList: 311
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6846
Advantage: 58

Less

View Lastest Price from Tafamidis Meglumine manufacturers

Hebei Mojin Biotechnology Co., Ltd

Product: Tafamidis Meglumine 951395-08-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-10-12

Hebei Guanlang Biotechnology Co., Ltd.

Product: Tafamidis Meglumine 951395-08-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2023-03-17

951395-08-7, Tafamidis MeglumineRelated Search:

2-(3,5-Dichlorophenyl)-6-benzoxazole carboxylic acid

6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole meglumine

cas 594839-88-0

PF06291826

PF-06291826

TAFAMIDIS;CAS 594839-88-0;PF-06291826;PF06291826

Tafamidis Meglumine

Tafamidis meglumine (Fx1006, PF06291826)

tafamidis meglumine,Inhibitor,Tafamidis,inhibit

Tafamidis-meglumine API

afamidis Meglumine

951395-08-7

C21H24Cl2N2O8

C7H17NO5C14H7Cl2NO3

API